ストレス条件下における中枢アミンの変動(心身症とアミン)(Psychosomatic Diseases and Amines)

概要

論文の詳細を見る
The change of brain monoamine levels and rectal temperature by immobilization were studied in rats.Male Wistar rats were immobilized with 3×3 mm wire mesh. Biochemical analyses of dopamine (DA), noradrenaline (NA), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were performed on the whole brains except cerebellum by the method of Welch and Welch. Immobilization started at 5 p. m.The results were ;1) Immobilization stress caused decreased rectal temperature.2) The rectal temperature of affected rats by gastric lesions was more decreased than that of the non-affected.3) The brain monoamine levels of DA, NA and 5-HT were not changed by immobilization.4) The brain 5-HIAA was significantly increased 1 hour and 12 hours after immobilization.It was supposed that the increase of the brain 5-HIAA could be caused by increased turnover of the 5-HT which might be induced by immobilization.
日本心身医学会の論文
1974-02-01