ワモンゴキブリの電位依存性ナトリウムチャネルに対するアキサジアジン系殺虫剤インドキサカルブの抑制作用

概要

論文の詳細を見る
The effects of the oxadiazine insecticide, indoxacarb, and its N-decarbomethoxylated metabolite (DCJW) on voltage-gated sodium channels in dorsal unpaired median (DUM) neurons isolated from American cockroach, Periplaneta americana, were studied using a whole-cell patch clamp technique. Both indoxacarb and DCJW suppressed the peak sodium currents in a time dependent manner. Indoxacarb and DCJW at 1μM blocked the sodium currents to 39.0±5.9% (n=3) and 3.2±0.2% (n=3) of the control after 25 min of bath application. Thus, indoxacarb was less potent than DCJW in blocking sodium currents in cockroach DUM neurons. However, the potency of indoxacarb in insect neurons observed in the present study was at least 100 times higher than that in rat dorsal root ganglion neurons reported previously.
日本応用動物昆虫学会の論文
2003-02-25