バイオフィードバック療法を施行した不安神経症の2症例 : 免疫学的指標と治療効果の関連性について

概要

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We provided biofeedback (BF) therapy for the purpose of relaxation of two patients who showed anxiety, tension and hypochondriacal symptoms and were diagnosed as a generalized anxiety disorder according to DSM-III-R. During the therapy from 3 to 10 months, two patients were received to be studied for clinical symptoms, MAS and CAS scale and immunological indicators including natural killer (NK) cell activity and proportion of lymphocyte subsets. One of the patients (Case 1) responded effectively to the therapy and showed improvement of the symptoms, a decrease of MAS and CAS scores and an increase in NK cell activity. In contrast, the above indicators were not changed in the other patient (Case 2) who did not show to be effective to the therapy. Both cases showed no change in the proportion of T cell subsets such as CD 4 or CD 8 bearing cells in preand post-treatment of BF. The results obtained from these two cases indicate the good correlation between improvement of symptoms in anxiety neurosis and NK cell activity. It is thus suggestive from our results that NK cell activity may be a good indicator to determine the effectiveness of BF therapy in a long-term therapeutic course.
日本心身医学会の論文
1995-10-01