ストレスと炎症細胞 : 特に気道過敏性亢進への影響(ストレス第29回日本心身医学会総会 1988年5月27日/於東京)

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This study was constructed to elucidate bronchial hypersensitivity due to stress by means of animal model. Bronchial hyperresponsiveness was evaluated in artificially ventilated guinea pigs, which inhaled 4.9〜156μg/ml of histamine solution via a nebulizer. Stress to the guinea pigs was loaded by means of restriction in a wire net for 8 hours. PC_<200> (provocative concentration of histamine needed for double-time increase of pulmonary resistance from baseline) was tended to decrease in the restriction stress group compared with the control group. This increase of bronchial responsiveness due to restriction stress was not inhibited by pretreatment of atropine 5mg/kg(ip).Total cell counts in broncho-alveolar lavage fluid (BALF) were not significantly different between the control group and the restricion group. The percentage of alveolar macrophage in BALF was significantly decreased, and the percentage of lymphocytes and eosinophils were significantly increased in the restriction stress group compared with the control group. The ability to produce active oxygens of BALF cells, which was evaluated by luminol-dependent chemiluminescence stimulated by A23187,was significantly increased in the restriction stress group as compared with the control group. Although the mechanism of these alterations of BALF cells was not clear, it was suggested the participation of active oxygens in increased bronchial responsiveness due to restriction stress.
日本心身医学会の論文
1989-02-01

ストレスと炎症細胞 : 特に気道過敏性亢進への影響(ストレス第29回日本心身医学会総会 1988年5月27日/於東京)

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ストレスと炎症細胞 : 特に気道過敏性亢進への影響(ストレス 第29回日本心身医学会総会 1988年5月27日/於東京)

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ストレスと炎症細胞 : 特に気道過敏性亢進への影響(ストレス第29回日本心身医学会総会 1988年5月27日/於東京)