<原著>モルモットにおけるin vivo肺圧量曲線におよぼす人工換気の影響

概要

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Effect of artificial ventilation on the lung elastic properties was investigated in the anesthetized, in vivo chest intact guinea pigs by using the body plethysmographic method. Absolute lung volume (functional residual capacity, FRC) of the guinea pigs was measured by Boyle's law technique during spontaneous respiration. Static pressure volume curve (PV curve) of the lung was constructed by the quasi-static inflation to total lung capacity (TLC, transpulmonary pressure 25 cmH_2O) and by the static deflation to FRC during muscle relaxation. In the guinea pigs (n=10), which were artificially ventilated for 60 minutes with positive end-expiratory pressure (PEEP) 0 cmH_2O, FRC and TLC were significantly decreased (p<0.01), and static PV curves were shifted to the right as compared with the pre-ventilation PV curves. In the guinea pigs (n=5), which were ventilated for 30 minutes with PEEP 3 cmH_2O, FRC and TLC were not changed and also PV curves were not changed as compared with the pre-ventilation PV curves. In the guinea pigs (n=5), which were ventilated for 30 minutes with PEEP 7 cmH_2O, FRC and TLC were significantly increased (p<0.01), and the static PV curves were shifted to the left as compared with the pre-ventilation PV curves. These changes of lung volumes and static PV curves were thought to be due to the changes (release, depletion, inactivation and movement) of the pulmonary surfactant.
近畿大学の論文
1987-06-25