<原著>ネコ摘出還流肺におけるメサコリン, ヒスタミン気管内投与の効果

概要

論文の詳細を見る
The effects of histamine and methacholine injected into the trachea were investigated on the isolated perfused cat lung and the influences on pulmonary circulation and airway reactivity were examined. Adult cats were anaesthetized with pentobarbital, and subjected to tracheostomy and artificial ventilation. Then the animals were exsanguinated through the cannula inserted to the pulmonary artery and left atrium beforehand. With autologous diluted blood, the lungs were perfused and a lung blood flow of 162.6-238.0ml/min held constant throughout the experiment was obtained. Drugs were injected into the trachea to provoke bronchoconstriction. The pulmonary arterial pressure (P_<PA>), flow rate (V) and tidal volume (V) were monitored. The lung resistance (R_L) was calculated by the manual graphic method. P_<PA> was not changed significantly by the tracheal injection of methacholine (0.5mg), but P_<PA> was increased with P_<AW> by the injection of histamine (100 μg) into the trachea, although the degrees of bronchoconstriction provoked by these drugs were about the same. Thus the authors concluded that the tracheal injection of histamine had more influences on pulmonary circulation than that of methacholine.
近畿大学の論文
1988-12-25