ストレスの生体防御に対する影響について : 当教室における研究をもとに(ストレスと免疫第29回日本心身医学会総会 1988年5月28日/於東京)

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The relationsip between stress and immunity has gradually become the current topics in the recent immunological field, and the investigation of this field has been established as psychoneuro-endocrino-immunology.A series of investigations which were conducted in our department in regard to the immunological modulation by stress involvement is shown in this paper. The study of the healthy public by the Stress Check List showed a variety of stress-related symptoms which suggest disturbed immunity among the people exposed to the chronic physical or psychological stress. The serums which were drawn from the donors whose uncomfortable states were induced by hypnosis showed depressed anti-bacterial immunity against Ebelthera typhosa and Shigela sonnei Ohara. The production of IgE in the mice which loaded 8 hours of restriction in the wire net for 4 days prior to the primary antigen-sensitization was remarkably depressed, where-as it was not in the mice whose stress were loaded after primary sensitization. Stress-related substances such as prostagrandin E_2(PG-E_2), α-and, β-endorphin were examined as to how they made effects on lymphocyte function. PHA-and PWM-imduced proliferative response and IgM production of human peripheral mononuclear lymphocytes were suppressed by PG-E_2. The α-, and β-endorphin enhanced T cell function such as PHA-induced proliferative response and IL-2 production in a lower concentration but did not modulate PWM-induced IgM production. These neuropeptides showed no effect or rather suppression in higher concentration. Suppressed lympocyte function by PG-E_2 was restored by the existence of α-endorphin. Stress-induced immunological modulation appears to require several factors such as the mode, occasion, and strength of loading stress.We tried to explain some part of phenomenon of stress-related immunological enhancement and suppression through these data and several references.
日本心身医学会の論文
1989-02-01

ストレスの生体防御に対する影響について : 当教室における研究をもとに(ストレスと免疫第29回日本心身医学会総会 1988年5月28日/於東京)

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ストレスの生体防御に対する影響について : 当教室における研究をもとに(ストレスと免疫 第29回日本心身医学会総会 1988年5月28日/於東京)

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ストレスの生体防御に対する影響について : 当教室における研究をもとに(ストレスと免疫第29回日本心身医学会総会 1988年5月28日/於東京)