末梢神経傷害後にNPYを発現する知覚神経節細胞について(鍼灸基礎)

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The mRNA signals and the immunoreactivity for neuropeptide Y(NPY)were seen in 20-30% of ipsilateral dorsal root ganglion (DRG) neurons, but rarely in contralateral ones (L4-5) after the unilateral transection of rat sciatic nerve. Most of NPY-like immuno-reactive (IR) neurons contained 200 kD subunit of neurofilaments and galanin. A few number of NPY-IR neurons was positive to calcitonin gene-related peptide (CGRP), and most of these neurons also displayed galanin-IR. Immunohistochemical analysis combined with retrograde-tracing method demonstrated that NPY-IR was detected in cutaneous and muscular sensory neurons but not in visceral sensory ones. These findings suggest that NPY co-exists with galanin, or both galanin and CGRP in injured large type A cells, which may innervate the low-threshold mechanoreceptors in the skin and muscle.
関西鍼灸大学の論文
1993-04-01