<研究論文>運動による糖尿病マウスの発病遅延及び寒冷暴露に対する抵抗力の向上

概要

論文の詳細を見る
The effect of exercise on diabetes was studied using C57BL db/db mice, which are known to develop diabetes following obesity. Exercise, swimming for 20 min at 35℃, three times per week, monday, Wednesday, and Friday, was started at 6 weeks old. The effect was determined by the blood glucose level and free heat release measured at 21℃ via a whole body calorimeter. Our findings was showed that although the blood glucose level in both the exercise and non-exercise groups increased steadily over age, the increase in the blood glucose level was slower in the exercise group than in the ono-exercise group; at 17 weeksold mean blood glucose was 340 mg/dl in the exercise group and 470 mg/dl in the non-exercise group; at 17 weeksold mean blood glucose was 340 mg/dl in the exercise group and 470 mg/dl in the non-exercise group. Free heat in the exercise group gradually increased from 19.8±5.7 at 11 weeks-old, 26.6±4.8 at 18 weeks-old and 30.6±4.1 KJoules/day at 26 weeks-old, while in the non-exercise group it was 22.3±6.6 at 11 weeks-old and at 18 weeks 21.7±6.8. At 26 weeks old all the non-exercise mice died during or immediately after measurements, but all the exercise mice survived. We speculate that our findings may suggest that exercise activates the metabolism of fatty acid, which subsequently slows the rise in the blood glucose level.
東海大学の論文