<原著>ウルソデスオキシコール酸の肝3-hydroxy-3-methylglutaryl coenzyme A reductaseと肝コレステロール7α-hydroxylase活性におよぼす作用

概要

論文の詳細を見る
The activity of hepatic 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA) reductase and 7α-hydroxylase, which are the enzymes controlling the rate of hepatic synthesis respe-ctively, in the cholesterol and bile acids were studied in mice receiving ursodesoxycholic acid (0.5% of the diet) for 10days and in the microsomal fraction containing 10-4M ursodesoxycholic acid in vitro. Both the activities of HMG-CoA reductase and cholesterol 7α-hydroxylase were reduced in vivo and in vitro.On the basis these findings, it is suggested that the decreased rate of cholesterol synthesis and cholesterol degradation to bile acid may play a significant role in the elimination of cholesterol in the serum and liver after ursodesoxycholic acid feeding.
北海道医療大学の論文
1982-12-31