<原著>子宮頸部腺癌の形態発生に関する研究

概要

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We evaluated the morphological and histological features of the uterine cervix in 96 patients with cervical adenocarcinoma (12 in situ, 10 microinvasive, and 74 frankinvasive) as well as those of 250 women without disease. The maximum extension of early-stage endocervical-type adenocarcinoma was to the primary cleft, while that of early-stage endometrioid-type adenocarcinoma was to the deep tunnels area. It is suggested that endocervical-type adenocarcinoma originates from the primary cleft and that replacement of the normal gland epithelium by the adenocarcinoma proceeds from the superficial part of the cleft towards the deep part of the cervix. Endometrioid-type adenocarcinoma is considered to originate mainly from the deep tunnels, as well as from the ectopic endometrial glands. The maximum extent of type-A glandular dysplasia was to the primary cleft, while that of type-B glandular dysplasia was to the deep tunnels area. CEA was detected intracellularly and within the membrane in all endocervical-type adenocarcinomas. CEA was located in the same areas in 71.4% of type-A glandular dysplasias. It is suggested that type-A glandular dysplasia is the precursor of the endocervical-type of adenocarcinoma.
近畿大学の論文
1992-12-25