<原著>コラーゲンゲル培養法の制癌剤感受性試験への応用

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In this study, the usefulness of the collagen-gel culture method of testing anti-cancer drug sensitivity was examined. In collagen-gel matrix culture, the growth of fibroblasts was inhibited while cancer cells proliferated well and maintained their original characteristics. Cancer cell positive rate for cell cultures using the collagen-gel culture method was 84%, greater than those obtained with HTCA and monolayer methods, even though a smaller number of cells is required for the collagen-gel culture methods. Comparison the results of collagen-gel cultures with those obtained in nude mice showed that the results agreed in four out of six cases. These results suggest that the collagen-gel method is useful as a sensitivity test for the anti-cancer drugs and may be applied in clinical chemotherapy.
近畿大学の論文
1991-03-25

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