<原著>神経免疫疾患に対するステロイドパルス療法の検討

概要

論文の詳細を見る
The authors examined the efficacy of methylprednisolone pulse therapy for myasthenia gravis (MG) and multiple sclerosis (MS). Each of the three patients with MG showed a different reaction to the tensilon test. The signs that had improved by the tensilon test further improved by the therapy, but the signs that were unchanged by the tensilon test did not change by the therapy. This suggests that suppression of immunity by steroids is ineffective when postsynaptic receptors at the neuromuscular junction are impaired. Three patients with MS were evaluated according to Kurtzke's expanded disability status scale for several months after the therapy. Auditory brainstem response (ABR) improved in a patient with MS after the therapy. However brain MRI showed no remarkable change in the three patients with MS after the therapy. Thus the therapy is effective in the progressive stage, especially for sensory and urinary disturbances. This suggests that the therapy is effective in antiedematization at the acute phase of MS.
近畿大学の論文
1989-12-25