合成Angiotensin II analogsのSHRSPへの適用(II 予防および治療)(A 基礎的研究)

概要

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We synthesized some analogs of angiotensin II (A-II) to investigate the structure-activity relationships in relation to the appearance of A-II antagonistic effect. Next, synthetic A-II analogs were applied to SHRSP and WKY in order to examine the A-II antagonistic effect on severe hypertension of SHRSP. Studies of structure-activity relationships indicated that : 1) The free carboxyl group of C-terminal residue seemed to be essential for A-II antagonistic properties, 2) the guanidino side chain of Arg in position 2 was also important for antagonistic action. In both responses of A-II-induced blood pressure and A-II antagonistic potency, there was no remarkable difference between SHRSP and WKY. Infusion of A-II antagonist, which showed antagonistic activities, had no effect on blood pressure in both SHRSP and WKY. Therefore, it would be doubtful that peripheral A-II plays an important role for the development or maintenance of severe hypertension in SHRSP used in this test.
近畿大学の論文
1981-09-25