随時尿の蛋白/クレアチニン比を用いた蛋白尿の定量的評価

概要

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The accuracy of the protein/creatinine (P/Cr) ratio in a single voided urine sample for quantitative analysis of proteinuria was studied. In a study of 49 urine specimens obtained from 33 patients with primary renal disease, the protein content of a 24-hour urine collection was significantly correlated with the P/Cr ratio of each group of random urine samples, which were divided into 4 groups according to the time of voiding during a 24-hour period. Both the correlation coefficients and the slopes of the linear regression analysis were highest for the first voided morning specimens. When the 24-hour urinary protein excretion was corrected for body surface area, lean body mass and the expected daily excretion of creatinine, much better correlations were obtained between the two variables. While there was no significant correlation between the 24-hour urinary protein and the P/Cr ratio of the first voided morning specimens in patients with nephrotic-range proteinuria, an excellent linear correlation was still observed in a study of urine samples showing the P/Cr ratio of less than 10. The results of our study indicate that the P/Cr ratio of the first voided morning specimens provides a reliable estimate of the 24-hour urinary protein excretion in patients with primary renal disease unless they have massive proteinuria.
香川県立保健医療大学の論文