Identification of Antigenic Site Within hsc 70 by Serum Autoantibody in Patients with Cancer-associated Retinopathy
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概要
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In our previous studies, both recoverin and heat shock cognate protein 70 (hsc 70) were found as autoantigens recognized by sera from four patients with cancer-associated retinopathy (CAR) . In the present study on the mole-cular mechanism of antibody generation in CAR, we identified the antigenic site within hsc 70 by the patients' sera using deletion mutants of hsc 73. We expressed a series of deletion mutants of hsc 73 proteins and subjected then to western blot analysis. In western blot analysis, CAR patient's serum reacted with wild type hsp 70, but not with the C-terminal truncated mutants. This data demonstrated that the antigenic site was located within the C-terminus region of hsc 73 as identified by CAR patient's serum.
- 札幌医科大学の論文
著者
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Maeda Akiko
Department Of Agricultural Chemistry The University Of Tokyo
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Ohguro Hiroshi
Department Of Ophthalmology And Visual Science Sapporo Medical University School Of Medicine
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Maeda Tadao
Department Of Ophthalmology University Of Washington
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Maeda Akiko
Department Of Ophthalmology Sapporo Medical University School Of Medicine
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Ohguro Hiroshi
Department of Ophthalmology ,Sapporo Medical University School of Medicine
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MAEDA Akiko
Department of Agricultural Chemicatry, The University of Tokyo
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Maeda Tadao
Department of Ophthalmology ,Sapporo Medical University School of Medicine
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