Combined Administration of L-Cystine and L-Theanine Enhances Immune Functions and Protects against Influenza Virus Infection in Aged Mice
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概要
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Cell-mediated and humoral immune responses are attenuated with aging. Intracellular glutathione (GSH) levels also decrease with aging. Previously, we have reported that combined administration of L-cystine and L-theanine enhances antigen-specific IgG production, partly through augmentation of GSH levels and T helper 2-mediated responses in 12-week-old mice. These findings suggest that combined administration of L-cystine and L-theanine to aged mice improves immune responses via increase of GSH synthesis. Here, we examined the effects of combined administration of L-cystine and L-theanine on antigen-specific antibody production and influenza virus infection in aged mice. Combined administration of these amino acids for 14 days before primary immunization significantly enhanced the serum antigen-specific IgM and IgG levels in 24-month-old mice. Furthermore, 13-month-old mice co-treated with these amino acids orally for 10 days had significantly lower lung viral titers than controls at 6 days after influenza virus infection. In addition, this co-treatment also significantly prevented the weight loss associated with infection. Enhancement of anti-influenza-virus IgG antibodies by combined administration of L-cystine and L-theanine was seen 10 days after infection. The significantly elevated serum interleukin-10/interferon-γ ratio and γ-glutamylcysteine synthetase mRNA expression, which is the rate-limiting enzyme of GSH synthesis, in the spleen 3 days after infection may have contributed to the observed beneficial effects. These results suggest that combined administration of L-cystine and L-theanine enhances immune function and GSH synthesis which are compromised with advanced age, and may become a useful strategy in healthy aging.
著者
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Takagi Yasuhiro
Division of Cardiology, Department of Medicine, Nihon University School of Medicine
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Maeda Akiko
Department Of Agricultural Chemistry The University Of Tokyo
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Kase Tetsuo
Division Of Virology Osaka Prefectural Institute Of Public Health
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KURIHARA Shigekazu
Research Institute for Health Fundamentals, Ajinomoto Co., Inc.
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MORIKAWA Saeko
Division of Virology, Osaka Prefectural Institute of Public Health
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HIGASHI Natsumi
Division of Virology, Department of Infectious Diseases, Osaka Prefectural Institute of Public Healt
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ARISAKA Harumi
Research Institute for Health Fundamentals, Ajinomoto Co., Inc.
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SHIBAHARA Susumu
Research Institute for Health Fundamentals, Ajinomoto Co., Inc.
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AKIYAMA Yukio
Research Institute for Health Fundamentals, Ajinomoto Co., Inc.
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Kurihara Shigekazu
Research Institute For Health Fundamentals Ajinomoto Co. Inc.
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Takagi Yasuhiro
Division Of Cardiology Department Of Medicine Nihon University School Of Medicine
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