Review: Clinical and Pathological Aspects of Cancer-Associated Retinopathy (CAR)

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概要

• 論文の詳細を見る

• Cancer-associated retinopathy (CAR) is an ocular manifestation of para-neoplastic syndrome and is further classified into two distinct diseases, CAR and MAR (melanoma-associated retinopathy) . CAR is associated with epithe-lial cancers, mostly lung small cell carcinoma, and is characterized by retini-tis pigmentosa-like retinal degeneration, such as ring scotoma, night blind-ness, and lowering of a and b-waves in electroretinogram (ERG) . Usually CAR can be found before an underlying primary cancer is diagnosed. In con-trast, MAR is associated with cutaneous malignant melanoma and is characte-rized by the relatively sudden onset of photophobia, nyctalopia, and lowering of b-wave in ERG. Histopathological study has revealed that photoreceptor and bipolar degeneration are primarily involved in CAR and MAR, respec-tively. Both CAR and MAR are believed to result from an autoimmune basis. In CAR, a calcium binding protein called recoverin, heat shock cog-nate protein 70 (hsc 70) , and other proteins are identified as retinal autoanti-gens, while the retinal antigens in MAR have not yet been identified. In this text, we review up-to-date information about the clinical and pathological aspects of these diseases.

• 札幌医科大学の論文

著者

• Maeda Akiko

  Department Of Agricultural Chemistry The University Of Tokyo

• Tadao Ogawa

  Department Of Ophthalmology Sapporo Medical University School Of Medicine

• Maeda Tadao

  Department Of Ophthalmology University Of Washington

• Akiko Maeda

  Department of ophthalmology, Sapporo Medical University School of Medicine

• Ogawa Keiichi

  Department of ophthalmology, Sapporo Medical University School of Medicine

• MAEDA Akiko

  Department of Agricultural Chemicatry, The University of Tokyo

• Maeda Tadao

  Department of Ophthalmology ,Sapporo Medical University School of Medicine

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