<Originals>Rat behaviors in artificial septal syndrome
スポンサーリンク
概要
- 論文の詳細を見る
In 1953,Nauta and Brady described characteristic behavioral changes following septal nucleus destruction in rats which had never been seen in a normal physiological state. The pathognomonic symptoms are called rat septal syndrome, and many reports have been described since then. The cardinal symptoms of this syndrome is hyper-emotionality associated with extreme excitement. In this report, we used rats as subject animals just like Nauta, Brady and other succeeding researchers did. Six non-brain-injured normal control rats, six rats of electrical unilateral destruction of the septal nucleus, six unilaterally prefrontal cortex destructed rats were used as the subject animals in this study. Six outside stimuli in the visual, auditory and tactile sensorial modes were administered to the subject animals, and their reactive behavioral changes were observed. Behavioral ratings were evaluated in five degrees from 0 to 4 points. Zero indicated no reaction and 5 points meant a very severe reaction. The results were as follows : the six septum destroyed rats showed typical septal syndrome, with symptoms in total correspondence with those reported by Nauta and Brady. On the other hand, the six prefrontally destructed rats and the six non-brain-injured normal control rats did not indicate the symptoms at all. These septal syndrome symptoms that the author found settled within about one month. The duration of this recovery period is average according to previous reports. In the author's observation, near the mid-point in the course of recovery, the rats displayed over-sedated or depressed behavior. About 14 days after the onset of septal syndrome, the rats seemed much hypoactive than normal state. No descriptions were found about such interesting behavioral changes in any previous reports. The underlying mechanisms for such a biphasic behavioral change to normalization have still not been revealed. From clinical stand point of view, general course of catatonic schizophrenia proposed by Karlbaum, or periodic catatonia proposed by Gjessing showed similar to some extent to rat septal syndrome, though it is a jump of logic to compare human behavior to rat behavior immediately. In this respect, rat septal syndrome might provide some insights to a certain area of the clinical neuropsychiatry.
- 近畿大学の論文
著者
関連論文
- A case of chronic and progressive choreiform movemetnt disorder with evident familial History
- Successful treatment of forced crying with levodopa in a case of vascular dementia
- Intellectual Functions in High Altitude : Neuropsychological Study in the Mountaineering Activities of K-13 Expedition of Kinki University Alpine Club 1981,Pakistan
- A case of Cotard's syndrome in an elderly woman
- School refusal and social situation in Japan
- A case of cimetidine-induced transient depressed state in an elderly woman
- Effects of Thyroxine, TRH and Metoclopramide on Transplantability of a Syngeneic Mammary Cancer in Mice
- Night-and-Morning Variation of Plasma Cortisol Concentrations in Healthy Subjects and Patients with Cushing's Syndrome
- Rat behaviors in artificial septal syndrome
- Paramnesia and Schizophrenia-Like Symptoms in a Hyperthyroid Patient after Thyroidectomy