Structure Activity Relationship Study of Dipeptide Antibiotic (+)-Negamycin for the Potent Readthrough Promoting Activity

スポンサーリンク

概要

• 論文の詳細を見る
• 2013-03-01

著者

• TAKAYAMA Kentaro

  Department of Biochemical Pharmacology, Center for Frontier Research in Medicinal Science and 21^

• Shiozuka Masataka

  Department Of Basic Human Sciences School Of Human Sciences Waseda University

• Yamazaki Yuri

  Department Of Medicinal Chemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences

• Yakushiji Fumika

  Department Of Medicinal Chemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences

• Hayashi Yoshio

  Department Of Chemistry Faculty Of Science Kanazawa University

• Hamada Keisuke

  Department Of Biochemistry Yokohama City University Graduate School Of Medicine

• Matsuda Ryoichi

  Department of Applied Chemistry Faculty of Engineering Tokushima University

• TAGUCHI Akihiro

  Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University

• YAKUSHIJI Fumika

  Department of Medicinal Chemistry, Tokyo University Pharmacy and Life Sciences

• KOTAKE Masaya

  Department of Medicinal Chemistry, Tokyo University Pharmacy and Life Sciences

関連論文

• Development of New Photoresponsive Paclitaxel Prodrug
• Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
• "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
• "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
• Design and Synthesis of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity
• Controlled Drug Release : Design and Application of New Water-soluble Prodrugs
• Spontaneously Regenerable Prodrug : Design and Synthesis of Water-soluble Prodrugs of HIV Protease Inhibitors
• Design of Double-Drug-Type Anti-HIV Agents
• Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of mdx Mice
• Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
• The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
• Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
• P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT"
• Conversion of Polymer-Bound Dipeptide to Evans-Type Chiral Auxiliary : A New Tool for Efficient Solid-Phase Asymmetric Reactions
• Revised Japanese criteria for Sjogren's syndrome (1999) : availability and validity
• FEM-Based Electromagnetic Wave Simulator Running on Some Platforms by Use of Java and a Commercial Tool(Analytical and Simulation Methods for Electromagnetic Wave Problems)
• FEM-Based Electromagnetic Wave Simulator Running on Some Platforms by Use of Java and a Commercial Tool
• SPHINGOSINE-1-PHOSPHATE ACTIVATES QUIESCENT SATELLITE CELLS(Cell Biology and Morphology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• Development of Spontaneously Regenerable Water-Soluble Prodrugs Based on the Peptide Chemistry : Importance of Drug Release Time for the Improvement of Gastrointestinal Absorption
• Metastatic Prostate Carcinoma to the Mandible : Report of a case
• Malignant Melanoma in situ of the Lower Lip
• Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
• Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
• S-V-5 Satellite cell activation mediated with sphingosine-1-phosphate(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo))
• Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
• Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
• Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
• Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease
• MUSCLE SATELLITE CELL ACTIVATION IS ACCOMPANIED BY A DECREASE IN CELL SURFACE SPHINGOMYELIN(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
• Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
• Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
• P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION
• Modification of P4 Position in β-secretase (BACE1) Inhibitors Containing Phenylnorstatine
• Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
• Convenient and Regioselective Syntheses of 3, 4-Disubsutituted Δ^3-Pyrrolin-2-one Derivatives Starting from 2-Tosyl-3, 4-Disubstituted Pyrroles
• Evaluation of Peptidomimetic HTLV-I Protease Inhibitors Containing Hydroxymethylcarbonyl as a Transition-State Isostere
• O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids
• "Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants
• GROWTH FACTOR ARRAY FABRICATION USING AN INK JET PRINTER II(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• Growth Factor Array Fabrication Using a Color Ink Jet Printer(Cell Biology)
• Design and Synthesis of β-Secretase Inhibitors Containing Hydroxymethylcarbonyl Isostere as a Transition State Mimic
• Three-dimensional Quantitative Structure-Activity Relationship Analysis of RGD Mimetics as Fibrinogen Receptor Antagonists
• Chemical Synthesis of 71-meric Neuregulin 1-β1
• The Rate of Cell Growth Is Regulated by Purine Biosynthesis via ATP Production and G1 to S Phase Transition
• Mechanisms of Transfer into SCID Mice Reconstituted with Tissueinfiltrating Cells from Murine Model for Sjogren's Syndrome
• Large Cell Undifferentiated Carcinoma of the Parotid Gland Containing Malignant Oncocytic Change
• Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
• "O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42
• Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin
• Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
• Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption
• Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
• Small Peptide-based Medicinal Chemistry for Intractable Disease
• A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis
• New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
• P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
• Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines
• Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine
• Cytokines, Adhesion Molecules, and Immune Deviation in Autoimmune Salivary Gland Disease
• Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability
• Evaluation of Peptidomimetic Inhibitors against Malarial Protease Plasmepsin
• Dipeptide-Type Inhibitors Targeting Plasmepsins from Plasmodium Falciparum
• Analysis of Side Reaction in the Amide Bond Formation with an α-Hydroxy-β-amino Acid as an Acyl Componemt
• Substrate Transition-State Analogue Inhibitors of Plasmepsin II as Antimalarial Drugs
• An Approach for Peptidic Aspartic Protease Inhibitors Using Ala-containing Oligopeptides Independent of the Substrate Sequence
• Development of a New Synthetic Method for L-Tetrahydrofuranylglycine and Its Application for Substrate-based HIV-1 Protease Inhibitors
• GROWTH FACTOR ARRAY FABRICATION USING AN INK JET PRINTER III(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• Carcinoma in Pleomorphic Adenoma of the Tongue : Report of a case
• O-N Intramolecular Acyl and Acyloxy Migration Reaction in the Development of Water-Soluble Prodrugs of Taxoids
• A Novel Method for the Synthesis of Difficult Sequence-Containing Peptides via O-Acyl Isopeptides : The Use of O-N Intramolecular Acyl Migration Reaction
• Development of New Water-Soluble Prodrugs Based on Intramolecular Nucleophilic Reactions in Peptide Chemistry
• Activin A Inhibits Differentiation of Chick Myogenic Cells In Vitro
• DEVELOPMENT OF DUAL-REPORTER TRANSGENIC MICE FOR READTHROUGH ASSAY(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• EFFECT OF TGF-β ON DIFFERENTIATION OF MYOGENIC SATELLITE CELLS(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• ROLES OF HGF/SF AND N-CADHERIN FOR MIGRATION OF SOMITIC MYOGENIC CELLS(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• ROLE OF HGF/C-MET SIGNALING IN SOMITE MYOGENESIS(Developmental Biology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
• Delivery of small interfering RNA with a synthetic collagen poly (Pro-Hyp-Gly) for gene silencing in vitro and in vivo
• Epitope mapping of anti-α-fodrin antibody in a case of early-onset multiple sclerosis
• Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice
• Transdermal delivery of a readthrough-inducing drug : a new approach of gentamicin administration for the treatment of nonsense mutation-mediated disorders
• Negamycin can restore dystrophin in mdx mouse skeletal muscles in vivo and in vitro(Symposium on Current Research for Skeletal Muscle)
• Crucial Role of Tissue-specific Apoptosis on the Development of Primary Sjogren's Syndrome
• Improved Serum-free Defined Medium for Proliferation and Differentiation of Chick Primary Myogenic Cells(Developmental Biology)
• Development of a Solid-supported Biotinylation Reagent for the Efficient Biotin Labeling to the SH group of Peptides and Small Molecules
• Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure
• Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy
• Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent
• Unique cell membrane expression of topoisomerase-II alpha as a useful diagnostic marker of liposarcoma
• Crucial Roles of NF-κB for T Cell Activation
• Intramedullary Teratoma of the Thoracic Spinal Cord associated with Anomalies of the Vertebrae and Ribs : Case Report
• Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease
• Effects of Oxidation during Synthesis on Structure and Field-Emission Property of Tungsten Oxide Nanowires
• Development of (+)-Negamycin Derivatives with Potent Readthrough Activity for Duchenne Muscular Dystrophy Chemotherapy
• Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features
• Regulation of T cell activation in Sjogren's syndrome
• Medicinal Chemistry and Chemical Biology of Diketopiperazine-Type Antimicrotubule and Vascular-Disrupting Agents
• Toxicity of formaldehyde in experimental animals. Concentrations of the chemical in the elution from dishes of formaldehyde resin in some vegetables.:CONCENTRATIONS OF THE CHEMICAL IN THE ELUTION FROM DISHES OF FORMALDEHYDE RESIN IN SOME VEGETABLES
• Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of mdx Mice
• Structure Activity Relationship Study of Dipeptide Antibiotic (+)-Negamycin for the Potent Readthrough Promoting Activity

もっと見る 閉じる

スポンサーリンク