Activin A Inhibits Differentiation of Chick Myogenic Cells In Vitro
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概要
- 論文の詳細を見る
We investigated the effect of activin A on the in vitro differentiation of primary myogenic cells isolated from chick embryonic breast muscle. As judged by the morphology of the cells and accumulation of creatine kinase, activin A inhibited myogenesis in a dose-dependent manner. The inhibitory activity was reversibly suppressed by follistatin. Activin A also inhibited the expression of MyoD1. Our data also suggest that the inhibitory activity of activin A is exerted neither on proliferation of myoblasts or the growth of myotubes, but rather an early phase of differentiation following the withdrawal from cell cycle. A comparison of actions of activin A and TGF-β suggests that points of action is similar.
- 社団法人日本動物学会の論文
著者
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Kimura Ichiro
Department of Mechanical Engineering,Faculty of Science and Engineering,Saga University
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Shiozuka Masataka
Department Of Life Sciences Graduate School Of Arts & Science University Of Tokyo
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Shiozuka Masataka
Department Of Life Sciences Graduate School Of Arts & Sciences The University Of Tokyo
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Shiozuka Masataka
Department Of Life Sciences Graduate School Of Arts And Sciences The University Of Tokyo
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Shiozuka M
Department Of Life Sciences Graduate School Of Arts & Science University Of Tokyo
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Momoi Takashi
National Institute of Neuroscience, NCNP
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Shiozuka Masataka
Department Of Basic Human Sciences School Of Human Sciences Waseda University
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Shiozuka Masataka
Department Of Life Science The University Of Tokyo
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Momoi T
National Institute Of Neuroscience Ncnp
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Kimura Ichiro
Department Of Civil And Environmental Engineering Matsue National College Of Technology
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Kimura Ichiro
Department Of Basic Human Sciences School Of Human Sciences Waseda University
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MOMOI Takashi
National Institute of Neuroscience
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