Promoting Effects of Sucrose-rich Diet on N-Nitrosobis (2-oxopropyl) amine-induced Pancreatic Carcinogenesis in Hamsters
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that there is an association between pancreatic cancer and obesity, impaired glucose metabolism and diabetes based on excess dietary fat and sugar intakes. A number of studies have suggested that a high-fat diet increases development of carcinomas in various organs and possible risk factors for pancreatic cancer. However, how an excess sugar intake promotes pancreatic carcinogenesis is still unknown. In the present study, we investigated the influence of an excess sugar intake on pancreatic carcinogenesis by administration of a sucrose-rich diet in which starch was replaced by sucrose in order to contain the same calories and other nutrients. Two similar experiments were performed. Six-week-old male Syrian golden hamsters were given N-nitrosobis (2-oxopropyl) amine (BOP) at a dose of 50 and 20 mg/kg body weight as a carcinogen in Week 0 and 1, respectively. In Week 2, the animals were divided into control and experimental groups. In experiment 1, 15 animals received a control diet or sucrose-rich diet in which 100% of the starch was replaced by sucrose, respectively. Since five animals fed on the sucrose-rich diet died by Week 12, the diet was changed to a sucrose-rich diet in which 50% of the starch was replaced by sucrose. In experiment 2, 15 animals received a control diet or sucrose-rich diet in which 50 or 20% of the starch was replaced by sucrose, respectively. All animals were sacrificed 25 weeks after the start of the experiment, and histological examination of the pancreas was performed. No significant difference was seen in the body weight at the end of the experiment. There were no significant differences in the glycosylated hemoglobin (HbA1c) and serum triglyceride, total cholesterol and HDL-cholesterol levels between the control and sucrose-rich diet groups in experiments 1 and 2. The incidence and number of carcinomas increased in hamsters fed the sucrose-rich diet compared with the control diet in experiments 1 and 2. These results suggest that an excess sucrose intake may promote the development of pancreatic cancer in hamsters.
- 2010-03-01
著者
-
Sakamoto Akika
Division of Pathology, Bozo Research Center Inc.
-
Goya Michishi
RI Center, Nara Medical University
-
Degawa Yoko
RI Center, Nara Medical University
-
Mitsui Masayuki
Mitsui Consulting
-
Tsutsumi Masahiro
RI Center, Nara Medical University
-
Tsutsumi Masahiro
Ri Center Nara Medical University
-
Mori T
Ri Center Nara Medical University
-
Mori Toshio
Ri Center Nara Medical Univ.
-
Tamura Kazutoshi
Division Of Pathology Bozo Research Center Inc.
-
Sakamoto Akika
Division Of Pathology Bozo Research Center Inc.
-
Degawa Yoko
Ri Center Nara Medical University
-
Goya Michishi
Ri Center Nara Medical University
関連論文
- Absence of Mitochondrial DNA Displacement Loop Mutations in Hamster Pancreatic Duct Adenocarcinomas and Established Cell Lines
- Infrequent Mutation of Lysophosphatidic Acid Receptor-1 Gene in Hamster Pancreatic Duct Adenocarcinomas and Established Cell Lines
- Promoting Effects of Sucrose-rich Diet on N-Nitrosobis (2-oxopropyl) amine-induced Pancreatic Carcinogenesis in Hamsters
- 3-Amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) Sensitizes Mammalian Cells to UV Radiation by Causing The S-Phase Arrest, Not by Inhibiting The Repair of DNA Damage as Observed in Escherichia coli
- Three-Dimensional Analysis of Nuclear Localization of Repair Sites of UV-lnduced DNA Damage by Laser Scanning Confocal Microscopy in Human Cells
- Meldnin reduces ultraviolet-induced DNA damdge formation and killing rate in cultured human melanoma cells treated with DHA.
- Inhibition of Pancreatic Carcinogenesis by Shark Cartilage Proteoglycan in Hamsters
- DNA Repair Effect of Traditional Sweet Pepper Fushimi-togarashi : Seen in Suppression of UV-induced Cyclobutane Pyrimidine Dimer in Human Fibroblast
- Differential Effect of UV-B and UV-C on DNA Damage in L-132 Cells
- Mode of Gene Damage Induced by Exposure to UVB and Some Radical Species (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Enantioselective Oxidation of Diols by Secondary Alcohol Dehydrogenase from Geotrichum sp. WF9101
- Degradation of Vinyl Alcohol Oligomers by Geotrichum sp. WF9101
- Isolation and Characterization of a Strain of Bacillus megaterium That Degrades Poly(vinyl alcohol)
- UVB/UVC-responsive Intracellular Signaling Pathways : A Chronological and Comparative Study.
- Conformational Changes and Surface Properties of Legumin from Broad Beans in Relation to Its Thermal Aggregation
- Relationships of Molecular Forces to Rheological and Structural Properties of Legumin Gels from Broad Beans
- Relationship between the Thermal Denaturation and Gelling Properties of Legumin from Broad Beans
- In Situ Visualization of UV-Induced DNA Damage in Human Cell Nuclei Following Partial-Volume Irradiation.
- In Situ Visualization of UV-Induced DNA Damage and Its Repair in Human Fibroblasts
- Effect of Nonenzymatic Glycosylation on the Titers of Circulating Autoantibodies in Pemphigus and Pemphigoid
- Three-Dimensional Visualization of UV-Induced DNA Damage and Its Repair in Human Cells.
- Trp-P-1 inhibits the removal of both cyclobutane dimers and (6-4)photoproducts from the DNA of ultraviolet-inadiated E.coli.
- Effects of Ionic Compositions of the Medium on Monosodium Glutamate Binding to Taste Epithelial Cells
- Binding of Umami Substance to Plasma Membrane Isolated from Bovine Circumvallate Papillae
- A Reliable Method for Intratracheal Instillation of Materials to the Entire Lung in Rats
- Repression of DNA synthesis in UV-inadiated xeroderma pigmentosum variant cells is more severe than normal cells
- FLAVONOIDS PROTECT ULTRAVIOLET-B DNADAMAGE IN THE SEEDLINGS OF SOLANUM MELONGENA
- 219 Establishment and characterization of monoclonal antibodies against 2-acetylaminofluorene-DNA adducts(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- The Amount of DNA Damage Determines Ultraviolet-Radiation-Induced Cytotoxicity after Uniform- or Local-Cell Irradiation
- In Situ Visualization of UV-Microbeam-Induced DNA Damage Repair in Human Fibroblasts
- Infrequent Mutation of Lysophosphatidic Acid Receptor-1 Gene in Hamster Pancreatic Duct Adenocarcinomas and Established Cell Lines
- Promoting Effects of Sucrose-rich Diet on N-Nitrosobis (2-oxopropyl) amine-induced Pancreatic Carcinogenesis in Hamsters
- Cardiac Lesions Leading to Sudden Death in a Beagle