Application of Focal Cerebral Cooling for the Treatment of Intractable Epilepsy
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概要
- 論文の詳細を見る
Epilepsy is usually treated with medication, but adequate seizure control is still not achieved in over 30% of epilepsy patients, even with the best available agents. Surgical treatment is also performed for such patients, but is not always successful. Focal cooling of the brain using a thermoelectric device has recently been evaluated as an alternative to epilepsy surgery. Brain cooling was first proposed approximately 50 years ago as an effective method for suppressing epileptic discharges (EDs). Recent studies indicate that focal cooling of the brain to a cortical surface temperature of 20°C to 25°C terminates EDs without inducing irreversible neurophysiological dysfunctions or neuronal damage in the brain tissue. Several mechanisms have been proposed for the antiepileptic effects of focal cooling, including reduction in neurotransmitter release, alternation of activation-inactivation kinetics in voltage-gated ion channels, and the slowing of catabolic processes. Developments in the implantable cooling device with closed-loop cooling systems for seizure detection and focal cooling have been promoted in the field of neuromodulation, but several aspects remain uncharacterized concerning the hardware. Recent advances in precision devices have enabled the optimization of the implantable local cooling system, which may become clinically applicable in the near future.
- 社団法人 日本脳神経外科学会の論文
- 2010-09-15
著者
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FUJII Masami
Department of Neurosurgery, Yamaguchi University School of Medicine
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Fujii Masami
Department Of Neurosurgery Clinical Neuroscience Yamaguchi University School Of Medicine
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Oku Takayuki
Department Of Neurosurgery Kokura Memorial Hospital Kitakyushu Fukuoka
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Kajiwara Koji
Department Of Neurosurgery Clinical Neuroscience Yamaguchi University School Of Medicine
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Nomura Sadahiro
Department Of Neurosurgery Institute Of Neuroscience St. Mary's Hospital
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Imoto Hirochika
Department Of Neurosurgery Yamaguchi University School Of Medicine
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Imoto Hirochika
Departments Of Neurosurgery Yamaguchi University School Of Medicine
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Tanaka Nobuhiro
Department Of Cardiology Tokyo Medical University
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Kajiwara Koji
Department Of Electrical Engineering And Information System School Of Engineering The University Of
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Fujisawa Hirosuke
Department Of Neurosurgery Clinical Neuroscience Yamaguchi University School Of Medicine
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Suzuki Michiyasu
Departments Of Neurosurgery Yamaguchi University School Of Medicine
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Yamakawa Takeshi
Department Of Cardiology
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Fujii Masami
Departments Of Neurosurgery Yamaguchi University School Of Medicine
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Suzuki Michiyasu
Department Of Neurosurgery Clinical Neuroscience Yamaguchi University School Of Medicine
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Fujioka Hiroshi
Department Of Applied Chemistry The University Of Tokyo
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Saito Takashi
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Maruta Yuichi
Department Of Neurosurgery Graduate School Of Medicine Yamaguchi University
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Yamakawa Toshitaka
Kyushu Institute Of Technology Graduate School Of Life Science And Systems Engineering
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Oku Takayuki
Department Of Neurosurgery Graduate School Of Medicine Yamaguchi University
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Yamakawa Takeshi
Department Of Applied Medical Engineering Science Graduate School Of Medicine Yamaguchi University
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Imoto Hirochika
Department Of Neurosurgery Graduate School Of Medicine Yamaguchi University
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Tanaka Nobuhiro
Department Of Neurosurgery Graduate School Of Medicine Yamaguchi University
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Nomura Sadahiro
Department Of Neurosurgery Clinical Neuroscience Higher Biointegration Yamaguchi University Graduate School Of Medicine
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Suzuki Michiyasu
Department Of Neurosurgery Clinical Neuroscience Higher Biointegration Yamaguchi University Graduate School Of Medicine
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Saito Takashi
Department Of Agronomy Faculty Of Agriculture Tohoku University
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Suzuki Michiyasu
Department of Neurosurgery and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan
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