B型肝炎ウイルスジェノタイプB型感染高浸淫地区における感染実態の変遷

概要

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To elucidate genotypes of HBV carriers in a hyperendemic area for HBV genotype B infection and to examine the changes over time in genotypes responsible for acute hepatitis B, 430 HBsAg-positive HBV carriers were determined by genotypes and compared the literal translation of infection status according to two time-period groups: a group seen between 1990 and 1999 and a group seen between 2000 and 2009. In total, 45% had genotype B and 35% had genotype C in both time-period groups, indicating no changes in genotypes over time. Among 34 acute hepatitis B patients, the percentage of genotype B was significantly lower in the present group (5.9%) than in the past group (58.8%), while the prevalence of genotype A tended to have increased in the last 10 years. In conclusion, there was an increase in acute hepatitis B infection by genotype A in a hyperendemic area for genotype B infection, even though there was no large change of genotypes between the present and the past percentages of subjects. A nation-wide surveillance of HBV infection status is a matter of urgency in terms of the universal vaccination for HBV.
社団法人　日本肝臓学会の論文
2011-11-25