Local Recurrence as Immunoglobulin G4 (IgG4)-Related Disease 10 Years after Radiotherapy to Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

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概要

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• In 2000, a 48-year-old woman developed a left orbital mass with lacrimal gland involvement and then, in 2003, a right orbital mass with lacrimal gland involvement, both of which were diagnosed as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). She underwent 30 Gy external beam radiation to bilateral orbital lesions. The lymphoma cells in both lesions did not share the same clonality, as shown by amplification by polymerase chain reaction of the immunoglobulin heavy chain gene. Immunoglobulin light chain analysis by immunohistochemistry and messenger RNA in situ hybridization showed λ chain monotype in the left orbital lesion but κ chain monotype in the right orbital lesion. She developed recurrent left orbital mass with high uptake on fluorodeoxyglucose positron emission tomography fused with computed tomography in 2010, and excisional biopsy disclosed the formation of follicles and infiltration with immunoglobulin G4 (IgG4)-positive plasma cells mainly in interfollicular areas. The immunoglobulin light chain analysis showed the λ chain and κ chain bitype. With the immunohistopathological diagnosis of IgG4-related disease, the serum IgG4 level was found to show elevation at 376 mg/dL, and the patient chose observation. This is the first reported case of development of IgG4-related disease after bilataral orbital MALT lymphoma with external beam radiotherapy. [J Clin Exp Hematopathol 51(2) : 125-133, 2011]

• 2011-11-01

著者

• Itoh K

  Division Of Oncology And Hematology National Cancer Center Hospital East

• Itoh Kuniaki

  神戸大学 医学研究科腫瘍内科学

• Ichimura Koichi

  Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine

• Ishizawa Kenichi

  東北大学 血液･免疫病学分野

• Ishizawa K

  Department Of Rheumatology And Hematology

• Morito Toshiaki

  Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Itoh Kuniaki

  Hematology And Oncology Division National Cancer Center Hospital East

• Itoh Kuniaki

  Department Of Chemistry Faculty Of Science Kobe University

• Kawase Ichiro

  大阪大学 医学系研究科機能診断科学

• Ichimura Koichi

  Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Ichimura Koichi

  Department Of Pathology Okayama University Graduate School Of Medicine And Dentistry

• Yoshida Takashi

  Department Of Hematology Japanese Red Cross Nagoya First Hospital

• Ichimura Koichi

  Department Of Pathology And Molecular Diagnostics Aichi Cancer Center

• Ichimura Kouichi

  Department Of Pathology Okayama University Medical School And Graduate School Of Medicine Dentistry

• Ichimura Kouichi

  Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Yoshino Tadashi

  Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Yoshino Tadashi

  Department Of Pathology Okayama University

• Yoshino Tadashi

  Department Of Hematology Okayama Rosai Hospital

• Tamada Yasuhiko

  Department Of Dermatology Aichi Medical University Hospital

• Yoshida T

  Tohoku Univ. Sendai Jpn

• Matsuo Toshihiko

  Department Of Communications And Integrated Systems Tokyo Institute Of Technology

• Matsuo Toshihiko

  Department Of Ophthalmology Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti

• Yoshino Tadashi

  Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Yoshino Tadashi

  Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical

• Ichimura Koichi

  Department Of Pathology Okayama University Medical School And Graduate School Of Medicine Dentistry

• Yoshino Tadashi

  Department Of Cytopathology Ayabe City Hospital

• Itoh Kuniaki

  Division of Hematology and Oncology, National Cancer Center Hospital East

• Yoshino Tadashi

  Department of Chemical Engineering, Hiroshima University

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