Association of Serum Uric Acid With Blood Pressure in Japanese Men : Cross-Sectional Study in Work-Site Group

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概要

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• Background: It has been reported that elevated levels of serum uric acid are related to hypertension and cardiovascular disease. Recent studies, however, have found little association between hyperuricemia and hypertension. Methods and Results: The association of serum uric acid with blood pressure was examined in 3,960 Japanese male workers (18-64 years of age; mean age, 42.3±0.2 years). Systolic blood pressure was significantly correlated with serum uric acid. Multiple regression analysis also showed that both systolic and diastolic blood pressures were independently associated with serum uric acid. When subjects were divided into 6 groups according to blood pressure on the basis of the Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009), serum uric acid was elevated in a linear fashion as blood pressure increased. A similar relationship was found even in 3,608 subjects who were not taking anti-hypertensive or uric acid-lowering agents. In contrast, no relation was found between serum uric acid and blood pressure in 352 subjects taking anti-hypertensive medicine. Conclusions: Blood pressure is closely associated with serum uric acid. Serum uric acid might be associated with the increase in blood pressure, because there is no relation between serum uric acid and blood pressure in the subjects treated with anti-hypertensive medications. (Circ J 2011; 75: 2827-2832)

• 社団法人　日本循環器学会の論文
• 2011-11-25

著者

• Ohta Yuko

  Department Of Research And Development Kokando Co. Ltd.

• Ohya Yusuke

  Department Of Cardiovascular Medicine Nephrology And Neurology School Of Medicine University Of The

• Ouchi Yasuyoshi

  東京大学 医学部泌尿器科学

• Ouchi Y

  Department Of Geriatric Medicine Graduate School Of Medicine University Of Tokyo

• Ouchi Yasuyoshi

  Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo

• MATSUMURA Kiyoshi

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Ohtsubo Toshio

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Okubo Yasuhiro

  Department Of Geriatric Medicine University Of Tokyo

• Ohashi Yasuo

  Department Of Biostatistics Epidemiology And Preventive Health Sciences The University Of Tokyo

• Matsumura Kiyoshi

  Department Of Intelligence Science And Technology Graduate School Of Informatics Kyoto University

• Matsumura Kiyoshi

  Medicine And Clinical Science. Graduate School Of Medical Sciences Kyushu University

• Okubo Yasuhiro

  Department Of Geriatric Medicine The University Of Tokyo

• Ohtsubo Toshio

  Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University

• Fukuhara Masayo

  Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University

• Fukuhara Masayo

  Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University

• Oh-hashi Yasuo

  Epidemiology And Biostatistics School Of Health Science Faculty Of Medicine University Of Tokyo

• Ichishima Kunihiko

  Department Of Physiology Saga University Faculty Of Medicine

• Kansui Yasuo

  Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University

• Ohya Yusuke

  Department Of Cardiovascular Medicine Nephrology And Neurology School Of Medicine University Of The

• Goto Kenichi

  Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University

• SAKATA Satoko

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Sakata Satoko

  Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University

• Ichishima Kunihiko

  Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University

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