Prediction of Cognitive Function by Arterial Stiffness in the Very Elderly(Clinical Investigation)
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概要
- 論文の詳細を見る
Background Cognitive function is impaired in elderly subjects, so the aim of the present study was to determine the role of arterial stiffness on cognitive function. Methods and Results Cognitive function and arterial stiffness were assessed by the Mini-Mental State Examination (MMSE) and measurement of the brachial-ankle pulse wave velocity (PWV), respectively. The cross-sectional association of the MMSE score and PWV was studied in 203 subjects (87 men, 116 women), all of whom were 85 years old. Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score ≥24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group than in the normal MMSE group (25.0±0.8 vs 22.9±0.5m/s, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score. Conclusions These results suggest that cognitive function could be predicted by arterial stiffness, as assessed by the PWV, in the very old. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age.
- 社団法人日本循環器学会の論文
- 2006-05-20
著者
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Fujii Koji
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University
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Yoshida Akihiro
Division of Cardiovascular Medicine, Himeji Cardiovascular Center
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TAKATA Yutaka
Division of Gastroenterology, National Kyushu Cancer Center
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MATSUMURA Kiyoshi
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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Takata Yutaka
Division Of General Internal Medicine Kyushu Dental College
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lida Mitsuo
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
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Fujisaki K
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University
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Matsumura Kiyoshi
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University
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Matsumura Kiyoshi
Department Of Intelligence Science And Technology Graduate School Of Informatics Kyoto University
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Matsumura Kiyoshi
Medicine And Clinical Science. Graduate School Of Medical Sciences Kyushu University
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Lida Mitsuo
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University
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ANSAI Toshihiro
Community Oral Health Science, Department of Health Promotion, Kyushu Dental College
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SONOKI Kazuo
Division of General Internal Medicine, Kyushu Dental College
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HAMASAKI Tomoko
Community Oral Health Science, Department of Health Promotion, Kyushu Dental College
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TAKEHARA Tadamichi
Community Oral Health Science, Department of Health Promotion, Kyushu Dental College
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FUKUHARA Masayo
Division of General Internal Medicine, Department of Health Promotion, Science of Health Improvement
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Ansai Toshihiro
Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improve
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Akifusa Sumio
Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improve
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Wakisaka Masanori
Division of General Internal Medicine, Kyushu Dental College
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Hamasaki Tomoko
Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improve
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Fujisawa Kiyoshi
Division of General Internal Medicine, Kyushu Dental College
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Takehara Tadamichi
Division of Community Oral Health Science, Department of Health Promotion, Science of Health Improve
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Sonoki Kazuo
Division Of General Internal Medicine Kyushu Dental College
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Akifusa Sumio
Division Of Community Oral Health Science Department Of Health Promotion Science Of Health Improveme
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Ansai Toshihiro
Community Oral Health Science Department Of Health Promotion Kyushu Dental College
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Hamasaki Tomoko
Community Oral Health Science Department Of Health Promotion Kyushu Dental College
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Fukuhara Masayo
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Fukuhara Masayo
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University
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Takehara Tadamichi
Community Oral Health Science Department Of Health Promotion Kyushu Dental College
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Wakisaka Masanori
Division Of General Internal Medicine Kyushu Dental College
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Masuda Katsutoshi
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University
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Yoshida Akihiro
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Yoshida Akihiro
Community Oral Health Science Department Of Health Promotion Kyushu Dental College
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