A Low Ankle Brachial Index is Associated with an Increased Risk of Cardiovascular Disease: The Hisayama Study
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概要
- 論文の詳細を見る
Aim: Peripheral artery disease (PAD), defined as a decreased ankle brachial index (ABI), is a risk factor for cardiovascular disease; however, few studies have assessed the relationship between a low ABI and cardiovascular risks in Asian populations. We herein examined the relationship between the ABI and the development of cardiovascular disease in a Japanese community.Methods: A total of 2,954community-dwelling Japanese individuals without prior cardiovascular disease ≥ 40years of age were followed up for an average of 7.1years. The subjects' ABIs were categorized into the three groups: low (≤0.90), borderline (0.91-0.99) and normal (1.00-1.40). We estimated the relationship between the ABI and cardiovascular risk using a Cox proportional hazards model.Results: During the follow-up period, 134subjects experienced cardiovascular events. The incidence of cardiovascular disease across the ABI values was significantly different (p＜0.001). After adjusting for confounding factors, namely age, sex, systolic blood pressure, use of anti-hypertensive drugs, diabetes, total cholesterol, high-density lipoprotein cholesterol, obesity, smoking, alcohol intake and regular exercise, individuals with a low ABI were at 2.40-fold (95% confidence interval [CI] 1.14-5.06) greater risk of cardiovascular disease and 4.13-fold (95% CI 1.62-10.55) greater risk of coronary heart disease.Conclusions: Our findings suggest that individuals with an ABI of ≤ 0.90 have an increased risk of cardiovascular events, independent from traditional risk factors, in the general Japanese population.
- 一般社団法人 日本動脈硬化学会の論文
著者
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Kiyohara Yutaka
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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FUKUHARA Masayo
Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
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Hata Jun
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Fukuhara Masayo
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Ninomiya Toshiharu
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Yoshida Daigo
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Mukai Naoko
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Hirakawa Yoichiro
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Kitazono Takanari
Department Of Clinical Sciences Graduate School Of Medical Sciences Kyushu University
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Kojima Iwao
Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
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