高カロリー飼料条件下におけるOLETFラット由来の高血糖値QTL間の遺伝的相互作用

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概要

• 論文の詳細を見る

• The condition of hyperglycemia results from multiple genetic and environmental factors. In recent years much progress has been made with regards to the search for candidate genes involved in the expression of various common diseases including type 2 diabetes. However less is known about the specific genetic and environmental connections that are important for the development of the disease. In the present study, we used hyperglycemic congenic rats to address this issue. When given a normal diet, two hyperglycemic QTLs (quantitative trait locus), Nidd2/of and Nidd10/of, showed mild obesity and/or increased blood glucose in the oral glucose tolerance test. In a double congenic strain possessing both loci, these indices were not significantly different from those of either single congenic strain. In contrast, the double congenic strain fed a high-calorie diet showed significantly greater body weight than the single congenic strains or normoglycemic control rats. Although postprandial glucose levels of the double congenic rat were not further aggravated even on the high fat diet, it was notable that the postprandial insulin levels were drastically elevated. From these results, we constructed a novel model animal especially for the study of prediabetic hyperinsulemia, in which two QTLs and an additional dietary condition are involved. This may help to shed light on the genetic basis and gene-to-diet interaction during the early stage of type 2 diabetes.

• 2011-04-01

著者

• 松本 高太郎

  帯広畜産大学畜産学部臨床獣医学研究部門予防獣医療学分野

• 山田 宜永

  Laboratory Of Animal Breeding And Genetics Graduate School Of Agriculture Kyoto University

• 山田 宜永

  京都大学大学院農学研究科動物遺伝育種学研究室

• 小瀬 博之

  Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima

• MATSUMOTO Kozo

  Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima

• Yamada Taku

  Laboratory Of Applied Molecular Biology Department Of Applied Biochemistry Osaka Prefecture Universi

• Kose Hiroyuki

  徳島大学医学部

• Kose Hiroyuki

  Institute For Animal Experimentation University Of Tokushima School Of Medicine

• Yamada T

  京都大学大学院農学研究科動物遺伝育種学研究室

• Yamada Takahisa

  Laboratory Of Animal Breeding And Genetics Graduate School Of Agriculture Kyoto University

• TAKEDA Chiyo

  Graduate School of Human Life Science, Osaka City University

• KURITA Yuko

  Graduate School of Human Life Science, Osaka City University

• OCHIAI Kazuhiko

  Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima

• Kose Hiroyuki

  Division For Animal Research Resources Institute Of Health Biosciences The University Of Tokushima G

• Fukumura Tomoe

  Division For Animal Research Resources Institute Of Health Biosciences The University Of Tokushima G

• Kurita Yuko

  Graduate School Of Human Life Science Osaka City University

• Ochiai Kazuhiko

  Division For Animal Research Resources Institute Of Health Biosciences The University Of Tokushima G

• Yamada Takahisa

  Laboratory Of Animal Genetics Graduate School Of Science And Technology Niigata University

• Takeda Chiyo

  Graduate School Of Human Life Science Osaka City University

• 福村 智恵

  Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School

• 竹田 知世

  Graduate School of Human Life Science, Osaka City University

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