高血糖遺伝子座Nidd3/ofのOLETFラットアレルは優性遺伝する
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概要
- 論文の詳細を見る
The OLETF rat is a well-established model for the study of type 2 diabetes associated with obesity and has been shown to possess multiple hyperglycemic alleles in its genome. Here we focused on and carefully characterized one of the previously reported congenic strains, F.O-Nidd3/of that carries the OLETF allele of the Nidd3/of locus (also known as Niddm21 in the Rat Genome Database) in the normoglycemic F344 genetic background. A prominent finding was that the F1 progeny between the congenic and the F344 stain, whose genotype is heterozygote at the Nidd3/of locus, showed mild hyperglycemia equal to the parental congenic rat, suggesting that the OLETF allele is dominant. To our knowledge, this is the first study in which a diabetic QTL has been directly demonstrated to be dominant by using congenic strains.
- 社団法人 日本実験動物学会の論文
著者
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松本 耕三
北海道大学医学部附属実験動物施設
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松本 耕三
徳島大学 医学部 附属動物実験施設
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松本 耕三
Institute For Animal Experimentation University Of Tokushima School Of Medicine
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松本 耕三
徳島大学医学部附属動物実験施設
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小瀬 博之
Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima
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山田 宣永
Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
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MATSUMOTO Kozo
Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima
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松本 耕三
Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima
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YAMADA Takahisa
Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
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KOSE Hiroyuki
Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima
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Yamada Takahisa
Laboratory Of Animal Breeding And Genetics Graduate School Of Agriculture Kyoto University
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Kose Hiroyuki
Division For Animal Research Resources Institute Of Health Biosciences The University Of Tokushima G
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Kose Hiroyuki
Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School
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MATSUMOTO Kozo
Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School
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