Detection of a Quantitative Trait Locus for Intramuscular Fat Accumulation Using the OLETF Rat.

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概要

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• The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes. We showed that the OLETF rat exhibits higher levels of intramuscular fat content in Musculus longissimus as compared to the Fischer-344 (F344) rat. Our investigation was designed to identify quantitative trait loci (QTLs) contributing to the increased levels of intramuscular fat content by performing a whole-genome search using 108 F2 intercross obtained by mating the OLETF and the F344 rats. We identified one QTL responsible for intramuscular fat accumulation on rat chromosome 1 with a maximum lod score of 3.4, which accounts for 5% of the total variance. As expected, the OLETF allele corresponds to the increased levels of intramuscular fat content.

• 公益社団法人 日本獣医学会の論文

著者

• Miyake Takeshi

  Laboratory Of Animal Breeding And Genetics Graduate School Of Agriculture Kyoto University

• SASAKI Yoshiyuki

  Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University

• Taniguchi Yukio

  Laboratory Of Animal Breeding And Genetics Graduate School Of Agriculture Kyoto University

• Kose Hiroyuki

  Institute For Animal Experimentation University Of Tokushima School Of Medicine

• Tanomura Hideki

  Laboratory Of Animal Breeding And Genetics Graduate School Of Agriculture Kyoto University

• Yamada Takahisa

  Laboratory Of Animal Breeding And Genetics Graduate School Of Agriculture Kyoto University

• Matsumoto Kozo

  Institute For Animal Experiment Hokkaido University School Of Medicine

• MATSUMOTO Kozo

  Institute for Animal Experimentation, University of Tokushima School of Medicine

• MANABE Noboru

  Laboratory of Anatomy and Cell Biology, Graduate School of Agriculture, Kyoto University

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