Identification of a Locus for Susceptibility to Renal Cell Carcinoma in the Long-Evans Cinnamon Rat.

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概要

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• The Long-Evans Cinnamon (LEC) mutant rat shows higher incidence of renal cell carcinomas induced by a treatment with the chemical carcinogen N-diethylnitrosamine, as compared to the normal control rat. We performed the first genome-wide scan for genes responsible for susceptibility to chemically induced renal cell carcinoma in an F2 intercross obtained by mating the LEC and Fischer-344 (F344) rats. The genotype of 71 (F344 × LEC) F2 progenies was determined with the use of 338 simple sequence length polymorphisms (SSLPs) spread over the genome. The F2 rats which carried renal cell carcinoma were shown to possess the incidence of homozygosity of the LEC allele which is higher than that of the other genotypes at SSLP markers on chromosome 5 (χ2 = 17.5 for D5Rat21). Our linkage analysis has led to the revelation of a novel gene that influences susceptibility to renal cell carcinoma on rat chromosome 5.

• 公益社団法人 日本獣医学会の論文

著者

• Izumi Keisuke

  Second Department Of Pathology School Of Medicine The University Of Tokushima

• Wei Suwen

  Institute For Animal Experimentation University Of Tokushima School Of Medicine

• SASAKI Yoshiyuki

  Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University

• YAMADA Takahisa

  Institute for Animal Experimentation

• Hino Akiko

  Second Department Of Pathology School Of Medicine The University Of Tokushima

• Wei Kaichun

  Institute For Animal Experimentation University Of Tokushima School Of Medicine

• Matsumoto Kozo

  Institute For Animal Experiment Hokkaido University School Of Medicine

• YAMADA Takahisa

  Institute for Animal Experimentation, University of Tokushima School of Medicine, Kuramoto, Tokushima 770-8503, Japan

• WEI Kaichun

  Institute for Animal Experimentation, University of Tokushima School of Medicine, Kuramoto, Tokushima 770-8503, Japan

• WEI Suwen

  Institute for Animal Experimentation, University of Tokushima School of Medicine, Kuramoto, Tokushima 770-8503, Japan

• HINO Akiko

  Second Department of Pathology, University of Tokushima School of Medicine, Kuramoto, Tokushima 770-8503, Japan

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