高解像度眼底画像に対する Matched Filter 処理の臨床応用

概要

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【Purpose】To find automated diagnosis of retinopathy, the matched filters (Chaudhuri et al, 1989) were studied for retinopathy. The filters had been reported for a film-based fundus image of 2.5x105 pixels, and the image needed to be converted into a digital file with an image scanner. Now, direct digital images are available with more precise images than 107 pixels.【Methods and Subjects】Non compressed digital images were taken with a non mydriasis-type fundus camera, and images of green component were used. Fluorescein angiography was done for retinopathy, and the images were compared to the matched filters. Subjects were 11 normal volunteers and 25 patients with typical diabetic retinopathy, 7 patients with branch retinal vein occlusion, 18 patients with age-related macular degeneration, respectively.【Results】Fine retinal blood vessels, microaneurysms, neovascularization, dotted retinal bleedings and exudates were emphasized for diabetic retinopathy, but non-perfusion areas in fluorescein angiograms could not be made clear with the filters. 【Conclusion】The filters would be helpful for diagnosis of retinopathy, but the process could not alternate with fluorescein angiography. The filters were not good for the diseases of transparent part such as cataract or vitreous hemorrhage.
2010-12-01