口腔癌における cathepsin B 遺伝子の発現亢進

概要

論文の詳細を見る
Aberrations on the short arm of chromosome 8 (8p) have been observed in various types of carcinoma including oral cancer. In this study, 47 samples of oral squamous cell carcinoma (OSCC) were examined in order to evaluate the role of 8p in the carcinogenesis of OSCC. By real-time quantitative RT-PCR analysis, mRNA expression of cathepsin B gene, mapped at 8p22, was investigated. Overexpression of mRNA expression of cathepsin B gene was revealed in OSCCs than normal tissues in 38 of 47 cases (80.9%). And values of mRNA were correlated to clinicopathological profiles; significant differences were found in differentiation (P=0.035), tumor size (P=0.006), regional neck metastasis (P=0.009) and TNM stage classification (P=0.001). The results imply that cathepsin B would play some roles in advance of OSCC and confirm the involvement of chromosome 8p22 region. The present study suggests that cathepsin B could be a target for molecular therapeutic approach.
千葉医学会の論文
2007-12-01