Overexpression of cathepsin B gene in oral squamous cell carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
Aberrations on the short arm of chromosome 8 (8p) have been observed in various types of carcinoma including oral cancer. In this study, 47 samples of oral squamous cell carcinoma (OSCC) were examined in order to evaluate the role of 8p in the carcinogenesis of OSCC. By real-time quantitative RT-PCR analysis, mRNA expression of cathepsin B gene, mapped at 8p22, was investigated. Overexpression of mRNA expression of cathepsin B gene was revealed in OSCCs than normal tissues in 38 of 47 cases (80.9%). And values of mRNA were correlated to clinicopathological profiles; significant differences were found in differentiation (P=0.035), tumor size (P=0.006), regional neck metastasis (P=0.009) and TNM stage classification (P=0.001). The results imply that cathepsin B would play some roles in advance of OSCC and confirm the involvement of chromosome 8p22 region. The present study suggests that cathepsin B could be a target for molecular therapeutic approach.
- 2007-12-01
著者
関連論文
- 10. fMRIによる咀嚼運動と脳血流動態の検討(第1027回千葉医学会例会・第22回歯科口腔外科例会)
- Overexpression of cathepsin B gene in oral squamous cell carcinoma
- 16. 当科における顎下腺多形性腺腫症例の検討(第955回千葉医学会例会・第18回歯科口腔外科例会)
- 5. 睡眠時無呼吸症における肥満と顎顔面形態の特徴(第1009回千葉医学会例会・第21回歯科口腔外科例会)
- 20. 糖尿病と歯周疾患の関連について(第1000回千葉医学会例会・第20回歯科口腔外科例会)
- 20. 当科の過去19年間における悪性腫瘍非手術症例の検討(第975回千葉医学会例会・第19回歯科口腔外科例会)
- 19. 当科の過去19年間における悪性腫瘍予後不良例の検討(第975回千葉医学会例会・第19回歯科口腔外科例会)
- 18. 当科の過去19年間における悪性腫瘍症例の検討(第975回千葉医学会例会・第19回歯科口腔外科例会)
- KAI1遺伝子の舌扁平上皮癌の進展・転移への関与
- 口腔扁平上皮癌における Headpin 遺伝子(セリン・プロテアーゼ・インヒビター : serpin ファミリー)の発現減弱と過メチル化
- 口腔多発癌症例の臨床的観察
- 口腔癌における cathepsin B 遺伝子の発現亢進