Oral Administration of Lactic Acid Bacteria Isolated from Traditional South Asian Fermented Milk 'Dahi' Inhibits the Development of Atopic Dermatitis in NC/Nga Mice

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概要

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• We investigated the suppressive effect of lactic acid bacteria (LAB) isolated from traditional South Asian fermented milk `dahi on the development of atopic dermatitis (AD) using NC/Nga AD model mice. In the initial evaluation, we confirmed the effect of LAB on serum total IgE using ovalbumin (OVA)-induced type 1 allergy model mice. Forty-one bacterial strains isolated from dahi were evaluated for their ability to induce interleukin (IL)-12 production and suppress IL-4 production in splenocytes obtained from OVA-sensitized mice. Of the 41 strains tested, Lactobacillus delbrueckii subsp. lactis R-037 exhibited the greatest IL-12 induction, suggesting that it is a potent Th1 inducer. Oral administration of heat-treated R-037 significantly suppressed the elevation of serum total IgE in OVA-induced type 1 allergy model mice. In NC/Nga AD model mice, oral administration of heat-treated R-037 reduced inflammatory auricular thickness and alleviated the AD clinical score although the effect on serum total IgE level was unclear. Histopathological findings showed a tendency toward improvement of inflammation. Hyperkeratosis in particular showed improvement in dermatitis skin lesions. These results suggest that oral administration of R-037 may alleviate AD.

• 財団法人 学会誌刊行センターの論文
• 2009-06-01

著者

• Kitahara Mikio

  Life Science Research Laboratories Life Science Rd Center Kaneka Corporation

• Kitano Mitsuaki

  Frontier Biochemical And Medical Res. Laboratories Corporate Res. And Dev. Div. Kaneka Corp.

• Tategaki Airo

  Frontier Biochemical And Medical Research Laboratories Corporate Research And Development Division K

• Tanaka Hozumi

  Frontier Biochemical And Medical Research Laboratories Corporate Research And Development Division K

• Hamada Kazuya

  Frontier Biochemical And Medical Research Laboratories Corporate Research And Development Division K

• Miyamoto Taku

  Graduate School Of Natural Science And Technology Okayama University

• WATANABE Toyoaki

  Frontier Biochemical and Medical Research Laboratories, Corporate Research and Development Division,

• KISHIDA Hideyuki

  Frontier Biochemical and Medical Research Laboratories, Corporate Research and Development Division,

• Watanabe Toyoaki

  Frontier Biochemical And Medical Research Laboratories Corporate Research And Development Division K

• Kishida Hideyuki

  Frontier Biochemical And Medical Research Laboratories Corporate Research And Development Division K

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