LOX-1 : The Multifunctional Receptor Underlying Cardiovascular Dysfunction
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概要
- 論文の詳細を見る
Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces morphological changes for atheroma-formation. Lectin-like oxidized LDL receptor-1 (LOX-1) was identified as the receptor for oxLDL that was thought to be a major cause of endothelial dysfunction. LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but also to atherosclerotic-plaque formation, myocardial infarction and intimal thickening after balloon injury. Recent findings on the genetics of LOX-1 and the methodology to detect it and its ligands would further facilitate the examination of the receptors pathophysiological contribution in atherosclerosis. Furthermore, LOX-1-related tools might open new gateways from diagnosis to therapeutics for cardiovascular diseases. (Circ J 2009; 73: 1993-1999)
- 社団法人 日本循環器学会の論文
- 2009-10-20
著者
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Sawamura Tatsuya
Department of Bioscience, National Cardiovascular Center Research Institute
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FUJITA Yoshiko
Department of Vascular Physiology, National Cardiovascular Center Research Institute
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SATO Yuko
Department of Vascular Physiology, National Cardiovascular Center Research Institute
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Fujita Yoshiko
Department Of Vascular Physiology National Cardiovascular Center Research Institute
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Fujita Yoshiko
Department Of Pharmacology The University Of Tokushima Graduate School Of Medical Sciences
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Sato Yuko
Department Of Clinical Physiology Tokyo Metropolitan Institute Of Gerontology
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YOSHIMOTO Ryo
Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The Univers
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Otsui Kazunori
Department Of Vascular Physiology National Cardiovascular Center
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Yoshimoto Ryo
Department Of Pharmacology Graduate School Of Agriculture And Life Sciences The University Of Tokyo
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Yoshimoto Ryo
Department Of Vascular Physiology National Cardiovascular Center
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Fujita Yoshiko
Department Of Vascular Physiology National Cardiovascular Center
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Ogura Sayoko
Department of Internal Medicine, Faculty of Medicine, the University of Tokyo
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Ogura Sayoko
Department Of Vascular Physiology National Cardiovascular Center
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Ogura Sayoko
Department Of Internal Medicine Faculty Of Medicine The University Of Tokyo
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KAKINO Akemi
Department of Vascular Physiology, National Cardiovascular Center
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IWAMOTO Shin
Department of Vascular Physiology, National Cardiovascular Center
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Kakino Akemi
Department Of Vascular Physiology National Cardiovascular Center
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Iwamoto Shin
Department Of Vascular Physiology National Cardiovascular Center
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Sawamura Tatsuya
Department Of Vascular Physiology National Cardiovascular Center Research Institute
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Sawamura Tatsuya
Department Of Vascular Physiology National Cardiovascular Center
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Sawamura Tatsuya
Department Of Bioscience National Cardiovascuar Center Reserch Institute
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Sato Yuko
Department Of Applied Chemistry Faculty Of Engineering Kyushu University:jst-crest
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SATO Yuko
Department of Anesthesiology, Aichi Medical University School of Medicine
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