Endothelin and endothelial dysfunction
スポンサーリンク
概要
- 論文の詳細を見る
Nitric oxide (NO) and endothelin (ET) produced in endothelial cells are leading molecules which regulate vascular function. Failure of the physiological balance between these two molecules is usually referred to as endothelial dysfunction. ET was initially identified as a potent vasoconstrictive peptide. Three ET isoforms and two ET receptors have been identified. One of the isoforms, ET-1, plays a significant role in many cardiovascular diseases. On the other hand, oxidized low-density lipoprotein (oxLDL) is known to induce endothelial dysfunction. The endothelial receptor for oxLDL was cloned, and named lectin-like oxidized receptor-1 (LOX-1). Activation of LOX-1 generates reactive oxygen species (ROS), and acivates a transcriptional factor, nuclear factor κB (NFκB), resulting in down-regulation of NO and up-regulation of ET-1. LOX-1 might be a key molecule in the generation of endothelial dysfunction. In endothelial dysfunction, ET-1 is an aggravating factor of cardiovascular diseases. (Communicated by Masanori OTSUKA, M.J.A.)
- 日本学士院の論文
著者
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Sawamura Tatsuya
Department Of Bioscience National Cardiovascuar Center Reserch Institute
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MASAKI Tomoh
International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Wo
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MASAKI Tomoh
International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University
関連論文
- PE-086 New Insights into Oxidized LDL-induced RhoA and Rac1 Activation by an LOX-1-MT1-MMP Axis in Endothelial Dysfunction(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts
- PE-297 LOX-1 is Expressed in the Adipose Tissue of High-Fat Diet-Induced Obese Mice in Close Association with MCP-1(PE050,Diabetes 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-021 Left Ventricular Expression of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 during the Development of Heart Failure(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The
- PJ-664 LOX-1 plays a crucial role in RhoA-and Rac1-dependent signaling through Gi induced by oxidized low-density lipoprotein in endothelial cells(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-473 A Novel Role of LOX-1 in Monocyte Adhesion-Induced Gene Expression via Redox-Sensitive and Ca^ Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
- Pericardial Fluid From Patients With Ischemic Heart Disease Accelerates the Growth of Human Vascular Smooth Muscle Cells
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- Enhanced Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 (LOX-1) at the Culprit Lesion in Patients with Acute Coronary Syndromes
- PJ-217 Monocyte Adhesion Induces Gene Expression Mediated via LOX-1-dependent Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-325 Potentiated Angiogenetic Effects of LOX-1 via Induction of Vascular Endothelial Growth Factor in Ischemic Leg(PJ055,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- IS105 Inducible expression of LOX-1, a novel receptor for oxidized low density lipoprotein in vascular endothelial cells
- Increased Expression of Lectin-like Oxidized Low-density Lipoprotein Receptor 1(LOX-1)in Coronary Unstable Plaques Obtained by Atherectomy
- Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox
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- OJ-066 Revaluation of minimally or extensively oxidized low-density lipoproteins-induced extracellular signal-activated kinase 1/2 activation through Lox-1 in coronary smooth muscle cells(Lipid Disorders 1 (H) : OJ8)(Oral Presentation (Japanese))
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- IS033 A Novel Platelet-endothelium Interaction Mediated by Lectin-like Oxidized Ldl Receptor-1
- IS061 Increased Expression of LOX-1 in the Endothelial Cells of Diabetic Rat Arteries
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