Measuring Brain Tissue Oxygenation under Oxidative Stress by ESR/MR Dual Imaging System

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概要

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• The in vivo measurement of oxygen in tissues is of great interest because of oxygens fundamental role in life. Many methods have been developed for such measurement, but all have been limited, especially with regard to repeated measurement, degree of invasiveness, and sensitivity. We describe electron spin resonance (ESR) oximetry with paramagnetic oxygen-sensing probe for in vivo measurement of oxygen in brain tissues by home-made ESR/MR dual imaging spectroscopy. Lithium 5, 9, 14, 18, 23, 27, 32, 36-octa-n-butoxy-2,3-naphthlocyanine (LiNc-BuO) radical was employed as the solid oxygen-sensing probe, and we confirmed its ability to report partial pressure of oxygen (pO2) in brain tissues of live animals under normal and pathological conditions for more than a month. pO2 measurements could also be made repeatedly on the same animal and at the same location. The implantation site of LiNc-BuO in examined rats was verified by 0.5T magnetic resonance (MR) imaging. Septic-shock rats were used to monitor tissue oxygenation during pathological state. A decline in pO2 levels from severe hypotension during sepsis was detected, and generation of nitric oxide (NO) in brain tissues was confirmed by NO spin trapping. ESR oximetry using oxygen-sensing probe and NO spin-trapping can be used to monitor pO2 change and NO production simultaneously and repeatedly at the same site in examined animals.

• 日本磁気共鳴医学会の論文
• 2007-07-01

著者

• FUJII Hirotada

  School of Health Sciences, Sapporo Medical University

• SAKATA Motomichi

  School of Medicine, Sapporo Medical University

• ITOH Kouichi

  Department of Clinical Laboratory Medicine, Jichi Medical University

• Fujii Hirotada

  School Of Health Sciences Sapporo Medical University

• Fujii Hirotada

  School Of Health Science Sapporo Medical University

• Sakata Motomichi

  School Of Medicine Sapporo Medical University

• Itoh Kouichi

  Department Of Molecular Pharmacology Tokushima-bunri University

• Itoh Kouichi

  Department Of Clinical Laboratory Medicine Jichi Medical School

• Hirata Hiroshi

  Department Of Life Science Himeji Institute Of Technology

• PANDIAN Ramasamy

  Department of Internal Medicine, Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and

• KUPPUSAMY Periannan

  Department of Internal Medicine, Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and

• Pandian Ramasamy

  Department Of Internal Medicine Center For Biomedical Epr Spectroscopy And Imaging Davis Heart And L

• Kuppusamy Periannan

  Department Of Internal Medicine Center For Biomedical Epr Spectroscopy And Imaging Davis Heart And L

• Hirata Hiroshi

  Department Of Electrical Engineering Yamagata University

• Hirata Hiroshi

  Department Of Control Engineering

• Hirata Hiroshi

  Department Of Applied Computer Engineering

• ITOH Kouichi

  Department of Cardiovasology, Surugadai Nihon University Hospital

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