Development of an ESR/MR Dual-imaging System as a Tool to Detect Bioradicals
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概要
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A system combining electron spin resonance imaging (ESRI) with another imaging modality capable of enabling visualization of the distribution of bioradicals on an anatomical map of the specimens would be a superior biomedical imaging system. We describe the development of an ESR/MR dual-imaging system with one permanent magnet and the biomedical applications of this system. The magnetic circuit developed for the ESR/MR dual-imaging system consisted of the permanent magnet made of Fe-Nd-B, pole pieces, and poke. The permanent magnet was installed on the MR side only, and the ESR side was made of pole pieces only. The magnetic field was adjusted to 0.5T at MR and to 0.042T at ESR. The overall dimensions of the magnet developed for the ESR/MR imaging system were 460 (W)×440 (D)×460 (H) mm, and it weighed 220 kg. The distance of each center for the magnet for ESR and MR imaging could be set as close as 200 mm. The entire ESR/MR imaging system can be installed in a common laboratory without magnetic shielding. MR images of plants (myoga) and small animals (mice and rats) were successfully acquired with or without ESR operation. ESR spectra of nitroxyl spin probes were also measured, even with MRI operation. ESR signals of triarylmethyl derivatives with narrow line-width (0.026 mT) were observed in living mice while MRI was operating. The ESR/MR imaging dual functions work properly with no electric or magnetic interference. The ESR/MR dual images demonstrate that this system enables visualization of the distribution of bioradicals on the anatomical map of the object.
- 2006-03-31
著者
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FUJII Hirotada
School of Health Sciences, Sapporo Medical University
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AOKI Masaaki
NEOMAX CO., LTD.
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HAISHI Tomoyuki
MR Technology Incorporated
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ITOH Kouichi
Laboratory of Molecular Pharmacology, Department of Pharmacy, Faculty of Pharmaceutical Sciences at
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SAKATA Motomichi
School of Medicine, Sapporo Medical University
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Aoki Masaaki
Neomax Co. Ltd
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Aoki Masaaki
Neomax Co. Ltd.
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Fujii Hirotada
School Of Health Sciences Sapporo Medical University
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Fujii Hirotada
School Of Health Science Sapporo Medical University
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Haishi Tomoyuki
Mr Technology Inc.
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Sakata Motomichi
School Of Medicine Sapporo Medical University
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Itoh Kouichi
Department Of Molecular Pharmacology Tokushima-bunri University
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Itoh Kouichi
Laboratory Of Molecular And Cellular Neurosciences Kagawa School Of Pharmaceutical Sciences Tokushim
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Itoh Kouichi
Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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