Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats
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概要
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Treatment of intracerebral hemorrhage is often pointless, although considerable effort has been devoted to developing treatments for ischemic stroke. The purpose of this study was to determine the influence of drugs in improving neurological outcomes with pharmaceutical therapy after intracerebral hemorrhage. The free-radical hypothesis for intracerebral hemorrhage is based on the cytotoxicity triggered by blood components and its degradation products, such as heme and iron as a potent pro-oxidant atom. Sulfaphenazole (SPZ) has a different mechanism such as reactive oxygen species scavenging, in addition to the inhibition of superoxide production by cytochrome P450. The present study investigated the properties of SPZ in collagenase-induced intracerebral hemorrhage rat brain damage. The results show that systemic SPZ treatment after intracerebral hemorrhage reduces striatal dysfunction, the elevation of lipid peroxidation, and brain edema in the rat. These results suggest that SPZ is a potentially effective therapeutic approach for intracerebral hemorrhage as the effect of SPZ was initiated for either 1 h or 3 d post-intracerebral hemorrhage.
著者
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Watanabe Masatomo
Laboratory Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima B
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Ishihara Yasuhiro
Laboratory Of Molecular Brain Science Graduate School Of Integrated Arts And Sciences Hiroshima Univ
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NAKAMURA YU
Department of Clinical Neuroscience & Psychiatry, Osaka University Graduate School of Medicine
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Nakamura Yu
Department of Neuropsychiatry, School of Medicine, Kagawa University
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Itoh Kouichi
Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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Ishihara Yasuhiro
Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University
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Hama Sayuri
Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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Danjo Sonoko
Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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Watanabe Masatomo
Laboratory of Molecular and Cellular Neurosciences, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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