Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains
スポンサーリンク
概要
- 論文の詳細を見る
The γ subunit of voltage-dependent Ca2+ channels (VDCCs) is characterized by molecular diversity and regulation of AMPA-type glutamate receptors as well as VDCCs. In the present study, we examined expressions for the VDCCγ1–8 subunit mRNAs in developing and adult mouse brains by in situ hybridization. In adult brains, the γ2 and γ7 subunit mRNAs were widely expressed in various grey matter regions with the highest level in cerebellar Purkinje cells and granule cells. The γ3 and γ8 subunit mRNAs predominated in the telencephalon, with the latter being at striking levels in the hippocampus. The γ4 subunit mRNA was enriched in the olfactory bulb, striatum, thalamus and hypothalamus. The γ5 subunit mRNA was abundant in the olfactory bulb, hippocampal CA2, thalamus, inferior colliculus and Bergmann glia. Transcripts of these subunits were detected in embryonic brains: some showed well-preserved spatial patterns (γ2, γ5, γ7 and γ8), while others underwent developmental up- (γ3) or down-regulation (γ4). In contrast, the γ1 and γ6 subunit mRNAs were negative or very low throughout brain development. Therefore, the present study has revealed spatial diversity in gene expression for individual VDCCγ subunits, presumably reflecting functional diversity of this protein family and their differential involvement in neural function.
- Elsevier Ireland Ltd and the Japan Neuroscience Societyの論文
- 2005-12-01
著者
-
WATANABE Masahiko
Department of Surgery, School of Medicine, Keio University
-
FUKAYA Masahiro
Department of Anatomy, Hokkaido University School of Medicine, Toya Lake Station for Environmental B
-
YAMAZAKI Maya
Department of Cellular Neurobiology, Brain Research Institute, Niigata University
-
SAKIMURA Kenji
Department of Cellular Neurobiology, Brain Research Institute, Niigata University
-
Yamazaki Maya
Department Of Cellular Neurobiology Brain Research Institute Niigata University
-
Sakimura Kenji
Department Of Cellular Neurobiology Brain Research Institute Niigata University
-
Fukaya Masahiro
Department Of Agricultural Chemistry College Of Agriculture Kyoto University
-
Watanabe Masahiko
Department Of Anaomy Hokkaido University School Of Medicine
-
Watanabe Masahiko
Department Of Anatomy School Of Medicine Hokkaido University
-
Watanabe Masahiko
Department Of Agricultural Chemistry The University Of Tokyo
-
Fukaya Masahiro
Hokkaido Univ. School Of Medicine Sapporo
関連論文
- Possible chemoresistance-related genes for gastric cancer detected by cDNA microarray
- UCN-01 (7-Hydoxystaurosporine) Inhibits in vivo Growth of Human Cancer Cells through Selective Perturbation of G1 Phase Checkpoint Machinery
- UCN-O1 (7-Hydroxystaurosporine) Enhances 5-Fluorouracil Cytotoxicity through Down-regulation of Thymidylate Synthetase Messenger RNA
- Dihydropyrimidine Dehydrogenase and Messenger RNA Levels in Gastric Cancer: Possible Predictor for Sensitivity to 5-Fluorouracil
- Autoantibodies and Cell-mediated Autoimmunity to NMDA-type GluRε2 in Patients with Rasmussen's Encephalitis and Chronic Progressive Epilepsia Partialis Continua
- III C1 Probable molecular dysfunction by autoantibodies against NMDA receptor GluRe2 in epilepsies after acute encephalitis
- Two different pathological conditions of photoparoxysmal responses in hereditary dentatorubral-pallidoluysian atrophy
- TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan
- Resistant Mechanisms of Anthracyclines-Pirarubicin Might Partly Break through the P-Glycoprotein-Mediated Drug-Resistance of Human Breast Cancer Tissues
- Development of endoscopic surgery for the minimally invasive treatment of digestive and other diseases
- Gene expression in colorectal cancer and in vitro chemosensitivity to 5-fluorouracil: A study of 88 surgical specimens
- NMDA Receptor GluN2B (GluRε2/NR2B) Subunit Is Crucial for Channel Function, Postsynaptic Macromolecular Organization, and Actin Cytoskeleton at Hippocampal CA3 Synapses
- Abundant distribution of TARP γ-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites
- Pouchitis atlas for objective endoscopic diagnosis
- Esophageal intramural pseudodiverticulosis (diffuse type)
- Distinct spatiotemporal expression of mRNAs for the PSD-95/SAP90 protein family in the mouse brain
- ADC Mapping of Benign and Malignant Breast Tumors
- Early establishment of lesion-insensitive mature barrelettes corresponding to upper lip vibrissae in developing mice
- Prominent expression of nuclear hormone receptor RORα in Purkinje cells from early development
- Cerebellum of the adult reeler mutant mouse contains two Purkinje cell populations with respect to gene expression for the N-methyl-D-aspartate receptor channel
- Machado-Joseph disease gene products carrying different carboxyl termini
- Rectal carcinoid arising in ulcerative colitis associated with rectal adenocarcinoma
- CLIPLESS LAPAROSCOPIC RESTORATIVE PROCTOCOLECTOMY USING AN ELECTROTHERMAL BIPOLAR VESSEL SEALER
- Diffuse Cavernous Hemangioma of the Rectum : Report of a Case
- Serrated adenoma developing into advanced colon cancer in 2 years
- Pyrimidine nucleoside phosphorylase and dihydropyrimidine dehydrogenase indicate chemosensitivity of human colon cancer specimens to doxifluridine and 5-fluorouracil, respectively
- Laparoscopic Ileocecal Resection for Crohn's Disease Associated with Intestinal Stenosis and Ileorectal Fistula
- Antitumor activity of delocalized lipophilic cation, MKT-077 in human carcinomas obtained from fresh surgical specimens
- Preventive Effect of Matrix Metalloproteinase Inhibitor, R-94138, in Combination with Mitomycin C or Cisplatin on Peritoneal Dissemination of Human Gastric Cancer Cell Line TMK-1 in Nude Mice
- Diffuse cavernous hemangioma of the rectum: MR imaging with endorectal surface coil and sphincter-saving surgery
- Serial Growth of Human Malignant Fibrous Histiocytoma Xenografts in Immunodeficient Mice
- The Modulating Effect of Interferon Alpha-2a on the Antitumor Activity of UFT Against a Human Gastric Carcinoma Xenograft, SC-1-NU, in Nude Mice
- Interictal and Ictal Magnetoencephalographic Study in Patients with Medial Frontal Lobe Epilepsy
- Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains
- A novel action of stargazin as an enhancer of AMPA receptor activity
- The Effects of Iodine-Doping on the Hetero-Epitaxial Growth of ZnS on GaP Substrates
- Molecular Mechanisms Governing Competitive Synaptic Wiring in Cerebellar Purkinje Cells
- Host-use pattern of the ragweed beetle Ophraella communa LeSage (Coleoptera: Chrysomelidae) for overwintering and reproduction in Tsukuba
- Upper cervical spine injuries : age-specific clinical features
- Upper cervical spinal cord tumors : review of 13 cases
- Mouse liaison for integrative brain research
- 産業用廃棄物ガラスを原料としたポーラスセラミックスの作製および評価
- Cytodifferentiation of Bergmann glia and its relationship with Purkinje cells
- Longitudinal magnetic resonance imaging study on whiplash injury patients : minimum 10-year follow-up
- Segmental Motor Paralysis After Expansive Open-Door Laminoplasty
- Intraspinal Cyst Communicationg With the Intervertebral Disc in the Lumbar Spine : Discal Cyst
- Impact of Longitudinal Distance of the Cervical Spine on the Results of Expansive Open-Door Laminoplasty
- Early genetic instability of both epithelial and stromal cells in esophageal squamous cell carcinomas, contrasted with Barrett's adenocarcinomas
- Aging of the Cervical Spine in Healthy Volunteers : A 10-Year Longitudinal Magnetic Resonance Imaging Study
- Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture
- Generation of L7-tTA Knock-in Mice
- Effect of agmatine on heteromeric N-methyl-D-aspartate receptor channels
- Unaltered pain-related behavior in mice lacking NMDA receptor GluRε1 subunit
- Glutamate Receptor Channels and Synaptic Plasticity
- Gastrointestinal Stromal Tumor of the Rectum Resected by Laparoscopic Surgery : Report of a Case
- Laparoscopy-Assisted Distal Gastrectomy for Early Gastric Cancer with Complete Situs Inversus : Report of a Case
- Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis
- Correlation of enhanced cell turnover with prognosis of gastrointestinal stromal tumors of the stomach : Relevance of cellularity and p27^
- Kinetics of Magnetite Formation in a Three-Phase System
- Kinetics of Ferrite Formation in a Three-Phase System
- The Lurcher mutation reveals Ca^ permeability and PKC modification of the GluRδ channels
- Modified N-methyl-D-aspartate receptor subunit expression emerges in reeler Purkinje cells after accomplishment of the adult wild-type expression
- Carbophosphinylation of Arynes with Cyanomethyldiphenylphosphine Oxide
- Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia, and endoneurial fibroblasts along rat sciatic nerves and its upregulation after crush injury
- Novel neuroglial and glioglial relationships mediated by L-serine metabolism
- Wingmorph- and Sex-specific Differences in Food Consumption, Fat Accumulation and Fat Consumption in a Cricket Modicogryllus confirmatus
- Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex
- Purification of Cytochrome P-450alk from n-Alkane-grown Cells of Candida maltosa, and Cloning and Nucleotide Sequencing of the Encoding Gene(Microbiology & Fermentation Industry)
- Identification of Polyethylene Glycols (PEGs)-assimilable Bacteria and Culture Characteristics of PEG 6000 Degradation by a Mixed Culture : Micro Degradation of Synthetic Polymers (III) See Reference 1).
- Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella
- Glutamate Receptor δ2 Is Essential for Input Pathway-Dependent Regulation of Synaptic AMPAR Contents in Cerebellar Purkinje Cells
- Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice
- Prospective Ten-Year Follow-up Study Comparing Patients With Whiplash-Associated Disorders and Asymptomatic Subjects Using Magnetic Resonance Imaging
- Molecular and Morphological Configuration for 2-Arachidonoylglycerol-Mediated Retrograde Signaling at Mossy Cell-Granule Cell Synapses in the Dentate Gyrus
- Retrospective, Matched Case-Control Study Comparing the Oncologic Outcomes Between Laparoscopic Surgery and Open Surgery in Patients with Right-Sided Colon Cancer
- A Novel Low-Molecular-Mass Dual-Specificity Phosphatase, LDP-2, with a Naturally Occurring Substitution That Affects Substrate
- Early onset of NMDA receptor GluRεl (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus
- Successful Laparoscopic Resection of a Sacrococcygeal Teratoma in an Adult : Report of a Case
- Genomic and Epigenetic Profiles of Gastric Cancer : Potential Diagnostic and Therapeutic Applications
- Clinical significance of tumor markers and an emerging perspective on colorectal cancer
- Conditional gene targeting on the pure C57BL/6 genetic background
- B-5-4 Structure of Lampterol(Terpenoids)
- Metastasis to the penis from cecum carcinoma
- Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells
- B2 exon splicing of nonmuscle myosin heavy chain IIB is differently regulated in developing and adult rat brain
- Photoperiodic Control of Adult Diapause, Cold Hardiness, and Inositol Accumulation in a Beetle, Aulacophora nigripennis(Coleoptera, Chrysomelidae)
- Prickle2 is localized in the postsynaptic density and interacts with PSD-95 and NMDA receptors in the brain
- Acute Cervical Spinal Cord Injury Complicated by Preexisting Ossification of the Posterior Longitudinal Ligament : A Multicenter Study
- Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate : report of a case
- Recent Trends in the Management of Achalasia
- IS1-07 Absent Smooth Muscle Actin Immunoreactivity of the Small Bowel Muscularis Propria Circular Layer in MMIHS
- IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses
- Development of endoscopic surgery for the minimally invasive treatment of digestive and other diseases.
- Biosynthesis of the neuron-specific enolase (14-3-2 protein) in a cell free system from wheat germ extract directed with poly(A)-containing RNA from rat brain.
- Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-flu
- A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine
- Development of an anatomical technique for visualizing the mode of climbing fiber innervation in Purkinje cells and its application to mutant mice lacking GluRδ2 and Ca_v2.1