ADC Mapping of Benign and Malignant Breast Tumors
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概要
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Purpose: The purpose of this study was to investigate the utility of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) value in differentiating benign and malignant breast lesions and evaluating the detection accuracy of the cancer extension. Materials and Methods: We used DWI to obtain images of 191 benign and malignant lesions (24 benign, 167 malignant) before surgical excision. The ADC values of the benign and malignant lesions were compared, as were the values of noninvasive ductal carcinoma (NIDC) and invasive ductal carcinoma (IDC). We also evaluated the ADC map, which represents the distribution of ADC values, and compared it with the cancer extension. Results: The mean ADC value of each type of lesion was as follows: malignant lesions, 1.22±0.31×10-3 mm2/s; benign lesions, 1.67±0.54×10-3 mm2/s; normal tissues, 2.09±0.27×10-3 mm2/s. The mean ADC value of the malignant lesions was statistically lower than that of the benign lesions and normal breast tissues. The ADC value of IDC was statistically lower than that of NIDC. The sensitivity of the ADC value for malignant lesions with a threshold of less than 1.6×10-3 mm2/s was 95% and the specificity was 46%. A full 75% of all malignant cases exhibited a near precise distribution of low ADC values on ADC maps to describe malignant lesions. The main causes of false negative and underestimation of cancer spread were susceptibility artifact because of bleeding and tumor structure. Major histologic types of false-positive lesions were intraductal papilloma and fibrocystic diseases. Fibrocystic diseases also resulted in overestimation of cancer extension. Conclusions: DWI has the potential in clinical appreciation to detect malignant breast tumors and support the evaluation of tumor extension. However, the benign proliferative change remains to be studied as it mimics the malignant phenomenon on the ADC map.
- 2005-06-01
著者
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OZAKI Masanori
Department of Electronic Engineering, Graduate School of Engineering, Osaka University
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Kuranami Masaru
Department Of Surgery School Of Medicine Kitasato University
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Kuranami Masaru
Department Of Surgery Kitasato University School Of Medicine
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WATANABE Masahiko
Department of Surgery, School of Medicine, Keio University
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Kan Sinichi
北里大学 医学部放射線科学
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Kan Sinichi
Radiology
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Kan Shinichi
Department Of Radiology Kitasato University School Of Medicine
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HAYAKAWA Kazushige
Department of Radiology and Radiation Oncology, Gunma University School of Medicine
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Watanabe Masahiko
Department Of Anatomy Hokkaido University School Of Medicine
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MATSUNAGA KEIJI
Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School
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IWABUCHI Keiichi
Pathology
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Hayakawa Kazushige
Department Of Experiment Radiology Oncology The University Of Texas M. D. Anderson Cancer Center
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IWABUCHI Keiichi
Department of Pathology, Kitasato University School of Medicine
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WOODHAMS Reiko
Radiology
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WOODHAMS Reiko
Department of Radiology, Kitasato University School of Medicine
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HATA Hirofumi
Department of Radiology, Kitasato University School of Medicine
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Iwabuchi Keiichi
Department Of Pathology Kitasato University School Of Medicine
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Hata Hirofumi
Department Of Radiology Kitasato University School Of Medicine
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Kan S
Departments Of Radiology Kitasato University School Of Medicine
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Matsunaga Keiji
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
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Ozaki Masanori
Department Of Electrical Electronic And Informational Engineering Osaka University
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Ozaki Masanori
Department Of Medical Engineering And Technology Kitasato University School Of Allied Health Science
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Watanabe Masahiko
Department Of Anaomy Hokkaido University School Of Medicine
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Watanabe Masahiko
Department Of Agricultural Chemistry The University Of Tokyo
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Woodhams Reiko
Department Of Diagnostic Radiology Kitasato University School Of Medicine
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Matsunaga Keiji
Department Of Diagnostic Radiology Kitasato University School Of Medicine
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