Kinetic Analysis of Water Transfer through Stratum Corneum by a Ventilated Chamber Measurement System
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概要
- 論文の詳細を見る
For a detailed analysis of the water barrier function of skin, it is necessary to obtain effective physical parameters related to the rate of transepidermal water loss (TEWL). By using a modified ventilated chamber measurement system, with high sensitivity and response, we have determined the apparent mass transfer coefficient of water, K, for the stratum corneum (SC) and the water vapor pressure, Pd, at the interface between SC and underlying living cells of epidermis from analyses of water distribution in the contact zone of carrier gas and skin surface. By data fit optimization of the calculated water flux to the measured one, the in vivo K value for human skin was determined to be (0.30 ± 0.14) × 10–8 kg/(m2·s·Pa) (n = 4, mean ± SD) which is close to the corresponding in vitro value of (0.12 ± 0.02) × 10–8 kg/(m2·s·Pa) (n = 6, mean ± SD) for porcine SC membranes. It is, therefore, concluded that the apparent mass transfer coefficient of water for SC can be estimated in vivo and noninvasively by the method developed in this study and will lead to a more precise and reliable evaluation of skin barrier function than the rate of TEWL itself.
- 社団法人 化学工学会の論文
- 2003-02-01
著者
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Suzuki Noboru
Department of Advanced Interdisciplinary Sciences, Graduate School of Engineering, Utsunomiya Univer
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SATO Masahide
Department of Physics,Nagoya University
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Endo K
Analytical Research Center Kao Corporation
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Endo Koji
Analytical Research Center Kao Corporation
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HOSHI MASATO
Analytical Research Center, KAO Corporation
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KATO TEIJI
Department of Applied Chemistry, Faculty of Engineering, Utsunomiya University
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ENDO ATSUSHI
Department of Applied Chemistry, Faculty of Engineering, Utsunomiya University
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FUJIKURA YOSHIAKI
Analytical Research Center, KAO Corporation
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Kato Teiji
Department Of Applied Chemistry Faculty Of Engineering Utsunomiya University
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Endo A
Department Of Applied Chemistry Faculty Of Engineering Utsunomiya University
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Sato M
Department Of Applied Chemistry Faculty Of Engineering Utsunomiya University
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Sato Masahide
Department Of Applied Chemistry Utsunomiya University
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Hoshi Masato
Department Of Molecular Pathology Tohoku University School Of Medicine
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Hoshi Masato
Analytical Research Center Kao Corporation
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Fujikura Yoshiaki
Analytical Research Center Kao Corporation
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Suzuki Noboru
Department Of Applied Chemistry Faculty Of Engineering Utsunomiya University
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Suzuki Noboru
Department Of Advanced Interdisciplinary Sciences Graduate School Of Engineering Utsunomiya Universi
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Sato Masahide
Department Of Advanced Interdisciplinary Sciences Graduate School Of Engineering Utsunomiya University
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