Natto Bacillus as an Oral Fibrinolytic Agent : Nattokinase Activity and the Ingestion Effect of Bacillus subtilis natto

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概要

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• Extraction of nattokinase, a fibrinolytic enzyme in natto bacillus, was attempted by the following 4 methods: 1) extraction with saline, 2) treatment with the organic solvents acetone, toluene and hexane prior to extraction, 3) alkaline treatment at pH 11.0 and, 4) autolysis in the presence of 0.1% NaN3 at 4\\xa1 C. Each fraction showed not only a strong fibrinolytic activity, but also H-D-Val-Leu-Lys-pNA and Suc-Ala-Ala-Pro-Phe-pNA amidolytic activities. Doses of 50–200 mg/kg natto bacillus (11011 active cells/g) were orally administered for rat experimental pulmonary thrombosis and to healthy human volunteers. A decrease in thrombus count and plasma euglobulin lysis time (ELT), as well as an increase in tissue plasminogen activator (t-PA), indicate that natto bacillus serves to activate plasma fibrinolysis in vivo.

• 社団法人　日本食品科学工学会の論文
• 2004-02-01

著者

• SUMI Hiroyuki

  Department of Physiological Chemistry, College of Science & Industrial Technology, Kurashiki Univers

• YATAGAI Chieko

  Department of Physiological Chemistry, Kurashiki University of Science and the Arts

• Sumi Hiroyuki

  Kurashiki University Of Science And The Arts

• Yatagai Chieko

  Department Of Physiological Chemistry Kurashiki University Of Science And The Arts

• YANAGISAWA Yasuhide

  Department of Physiological Chemistry, Kurashiki University of Science and the Arts

• SAITO Josuke

  Honda Trading Corporation

• Yanagisawa Yasuhide

  Chiba Institute of Science

• Saito Josuke

  Honda Trading

• Sumi Hiroyuki

  Department Of Nutritional Science Faculty Of Health And Welfare Science Okayama Prefectural Univ.

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