有機塩素系化合物および芳香族ニトロ系化合物に由来する活性酸素種のDNA損傷性

概要

論文の詳細を見る
According to the appointment of Ashby et al., 60% of the environmental carcinogens are negative in Ames test. About non-mutagenic carcinogens, it is reported that there is the relationship between carcinogenicity and the ability to produce active oxygen.We choosed organochlorine compounds which are non-mutagenic carcinogens and nitroarenes as test chemicals.As a means to evaluate the ability of chemicals to produce O2-, new strain which can detect soxS induced by O2- is used. And for positive compounds, umu test is tried. And whether the test with the new strain can become a way of screeing of non-mutagenic carcinogens is discussed.As a result of these tests, it is cleared that there are compounds which produce O2- and H2O2 induced by the O2- causes DNA damage. This result suggests that new strain can become a means to screen non-mutagenic carcinogens. Intensity of mutagenic activity of organochlorine compounds in umu test decreased when S9mix was added. When 1-naphthol and quinoline are nitrated, they become to produce O2-. Aromatic compounds existing in tar can get ability to produce O2- after nitrated and can cause DNA damage. Therefore the evaluation of toxic effects of active oxygen should be added to established tests.
社団法人　日本水環境学会の論文
1996-11-10