Tyrosine Kinase May Participate in Ca^<2+> Entry for Endothelial Nitric Oxide Production
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概要
- 論文の詳細を見る
We have suggested that cyclopiazonic acid (CPA), a Ca<SUP>2+</SUP>-ATPase inhibitor, produces nitric oxide (NO) by triggering a Ca<SUP>2+</SUP>-influx resulting from Ca<SUP>2+</SUP>-depletion in the endoplasmic reticulum of endothelial cells. The tyrosine kinase inhibitor methyl 2, 5-dihydroxycinnamate, while having no effect on relaxations induced by A23187 or Na nitroprusside, did inhibit the CPA-induced relaxation and cyclic GMP formation in rat aorta. Tyrosine kinase may participate in endothelial NO synthesis through activation of a Ca<SUP>2+</SUP> entry mechanism.
- 社団法人 日本薬理学会の論文
- 1995-02-01
著者
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Moritoki H
Univ. Tokushima Tokushima Jpn
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Moritoki Hideki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science University Of Tokushima
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Hisayama Tetsuhiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Hisayama Tetsuhiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokushima
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Kida K
Gifu Univ. School Of Medicine Gifu Jpn
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KIDA Kann
Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokushima
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IMADA Kazuye
Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokushima
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Imada Kazuye
Department Of Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokushima
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