The C677T Mutation in the Methylenetetrahydrofolate Reductase Gene among the Indonesian Javanese Population

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概要

• 論文の詳細を見る

• The presence of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene has been regarded as a genetic risk factor for coronary artery diseases and neural tube defects. Although the prevalence of this mutation has been reported from various ethnic populations, few data concerning Indonesian populations are available. We have investigated the frequency of the mutation in 68 Indonesian Javanese (residents of Java Island) and compared it with the data from 244 Japanese (residents of Honshu Island). The frequencies of the three genotypes in Javanese were C/C 0.84, C/T 0.16 and T/T 0.00, whereas those in Japanese were C/C 0.39, C/T 0.48 and T/T 0.13. The rarity of the T/T genotype in the Indonesian Javanese population may be due to malnutrition in pregnant women, because insufficient intake of folate is considered to be a survival disadvantage for fetuses with the T/T genotype. In conclusion, homozygosity for the C677T mutation in the MTHFR gene does not constitute a genetic risk factor for coronary artery diseases and neural tube defects in the Indonesian Javanese population.

• 神戸大学の論文

著者

• 李 明鎭

  神戸大学大学院 医学系研究科 公衆衛生学分野

• Matsuo M

  Department Of Pediatrics Graduate School Of Medicine Kobe University

• Lee M

  神戸大学医学系研究科

• Sutomo Retno

  神戸大学医学系研究科

• Sutomo Retno

  神戸大学 医系研究 公衛

• Sadewa Ahmad

  神戸大学医学系研究科

• Sadewa Ahmad

  神戸大学 医系研究 公衛

• Matsuo Masafumi

  神戸大学医学系研究科

• Hayashi Chiyo

  神戸大学医学系研究科

• Lee Myeong

  神戸大学医学系研究科

• Ayaki Hitoshi

  神戸大学医学系研究科

• Sofro Abdul

  Department of Biochemistry, Faculty of Medicine, Gadjah Mada University

• Nishio Hisahide

  神戸大学医学系研究科

• Lee Myeong

  神戸大学 医学研究科遺伝疫学

• Sofro Abdul

  Department Of Biochemistry Faculty Of Medicine Gadjah Mada University

• Lee Myeong　jin

  Department Of Public Health Kobe University Graduate School Of Medicine

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