PDGF-alpha Receptor Expression Following Hypoxic-Ischemic Injury in the Neonatal Rat Brain

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概要

• 論文の詳細を見る

• Hypoxia-ischemia (HI) causes injury to oligodendrocytes (OLs), cells which createthe myelin sheath in the developing brain. OLs pass successively through progenitorand immature stages during differentiation into mature OLs. Only the OLs in theprogenitors stage can express the platelet-derived growth factor-α receptor (PDGF-Rα)so that its expression is one of the cellular markers of OL progenitors. Activation ofPDGF-Rα results in OL proliferation, but not OL differentiation. To study the responseof OL progenitors after neonatal HI brain injury, we investigated the expression ofPDGF-Rα in a neonatal rat stroke model (combination of left common carotid arteryligation and exposure to 8% O2 for 2 h).In the injured cerebral cortex, PDGF-Rα mRNA levels increased significantly(p<0.01) with a peak at 0.5 h after HI insult, and returned to baseline levels within 48 hpost-injury. PDGF-Rα protein levels increased significantly at 72-96 h (p<0.05) andthen returned to basal levels. Immunohistochemistry showed clear staining ofPDGF-Rα only in the injured cerebral cortex at 72 h after HI insult. In contrast, nostaining was observed in the cortex of sham-operated controls.These results indicate that the expression of PDGF-Rα increases rapidly andtransiently only in the injured cerebral cortex after HI insult and may play a protectiverole through modulating the glial differentiation under the condition of cellular damagein the developing brain.

• 神戸大学の論文

著者

• 常石 秀市

  神戸大学医学部附属病院親と子の心療部

• 常石 秀市

  神戸大学医学系研究科

• 常石 秀市

  姫路市総合福祉通園センター

• Matsuo M

  Department Of Pediatrics Graduate School Of Medicine Kobe University

• Matsuo Masafumi

  Department Of Pediatrics Graduate School Of Medicine Kobe University

• Matsuo Masafumi

  Kobe University Graduate School Of Medicine

• TAKADA Satoshi

  Faculty of Health Science, Kobe University School of Medicine

• Takada Satoshi

  Faculty Of Health Sciences Kobe University School Of Medicine

• Morioka Ichiro

  Department Of Pediatrics Kobe University Graduate School Of Medicine

• Morioka Ichiro

  Kobe University Graduate School Of Medicine

• Mizutori Masakazu

  Department Of Pediatrics Graduate School Of Medicine Kobe University

• Tsuneishi Syuichi

  Kobe University Graduate School of Medicine

• Takada Satoshi

  Kobe University Graduate School Of Health Sciences

• Takada Satoshi

  Faculty Of Health Science Kobe University School Of Medicine

• Morioka Ichiro

  Kobe Univ. Graduate School Of Medicine Kobe Jpn

• Matsuo Masafumi

  Kobe Univ. Graduate School Of Medicine Kobe Jpn

• Matsuo M

  Kobe University Graduate School Of Medicine

• Tsuneishi Syuichi

  Faculty of Health Sciences, Kobe University School of Medicine

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