Plasma Surface Modification for Immobilization of Bone Morphogenic Protein-2 on Polycaprolactone Scaffolds

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概要

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• The immobilization of recombinant human bone formation protein-2 (rhBMP-2) on polycaprolactone (PCL) scaffolds was performed by plasma polymerization. RhBMP-2, which induces osteoblast differentiation in various cell types, is a growth factor that plays an important role in bone formation and repair. The surface of the PCL scaffold was functionalized with the carboxyl groups of plasma-polymerized acrylic acid (PPAA) thin films. Plasma polymerization was carried out at a discharge power of 60 W at an acrylic acid flow rate of 7 sccm for 5 min. The PPAA thin film exhibited moderate hydrophilic properties and possessed a high density of carboxyl groups. Carboxyl groups and rhBMP-2 on the PCL scaffolds surface were identified by attenuated total reflection Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, respectively. The alkaline phosphatase activity assay showed that the rhBMP-2 immobilized PCL scaffold increased the level of MG-63 cell differentiation. Plasma surface modification for the preparation of biomaterials, such as biofunctionalized polymer scaffolds, can be used for the binding of bioactive molecules in tissue engineering.

• 2013-11-25

著者

• Jung Sang

  Department Of Biology Seoul Women's University

• Kim Byung

  Department Of Aerospace Engineering School Of Engineering Nagoya University

• Myung Sung

  Department Of Nursing Wooridul Spine Hospital

• Kim Byung

  Department of Dental Materials, School of Dentistry, MRC Center, Chosun University, Gwangju 501-759, Republic of Korea

• Ko Yeong

  Department of Dental Materials, School of Dentistry, MRC Center, Chosun University, Gwangju 501-759, Republic of Korea

• Myung Sung

  Department of Dental Materials, School of Dentistry, MRC Center, Chosun University, Gwangju 501-759, Republic of Korea

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